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Merck
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重要文件

SAB4200197

Sigma-Aldrich

Anti-Periostin antibody,Mouse monoclonal

clone 47, purified from hybridoma cell culture

同義詞:

Periostin Antibody, Periostin Antibody - Monoclonal Anti-Periostin antibody produced in mouse, Anti-OSF2, Anti-Osteoblast specific factor 2, Anti-PDLPOSTN, Anti-POSTN

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

共軛

unconjugated

抗體表格

purified from hybridoma cell culture

抗體產品種類

primary antibodies

無性繁殖

47, monoclonal

形狀

buffered aqueous solution

分子量

antigen ~88 kDa

物種活性

human

濃度

~1.0 mg/mL

技術

western blot: 2-4 μg/mL using whole extracts of HEK-293T cells over expressing human Periostin

同型

IgG1

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... POSTN(10631)

一般說明

Periostin (POSTN) is also known as osteoblast-specific factor-2. It is a 90 kDa protein expressed in the extracellular matrix and bones. POSTN is an adhesive glycoprotein. The gene encoding this protein is localized on human chromosome 13q13.3.

免疫原

human Periostin recombinant protein. The human protein shares 87% homology with the mouse protein.

應用

Monoclonal Anti-Periostin antibody produced in mouse has been used to develop a periostin imaging PET probe.

生化/生理作用

Periostin (POSTN) has a role in the differentiation and cell adhesion of osteogenic cells. It functions as a biomarker of T-helper cells type 2-mediated inflammatory diseases. The protein has been associated with various cancers. POSTN is involved in epithelial-mesenchymal transition and extracellular matrix degradation.

外觀

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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存取文件庫

Imaging of secreted extracellular periostin, an important marker of invasion in the tumor microenvironment in esophageal cancer.
Heidari P, et al.
Journal of Nuclear Medicine, 56(8), 1246-1246 (2015)
Epithelial periostin expression is correlated with poor survival in patients with invasive breast carcinoma.
Kim G E, et al.
PLoS ONE, 12(11), e0187635-e0187635 (2017)
Functional role of periostin in development and wound repair: implications for connective tissue disease.
Hamilton D W.
Journal of Cell Communication and Signaling, 2(1-2), 9-9 (2008)
Bone marrow mesenchymal stem cells promote head and neck cancer progression through Periostin?mediated phosphoinositide 3?kinase/Akt/mammalian target of rapamycin.
Liu C, et al.
Cancer Science, 109(3), 688-698 (2018)
Mechanism of Periostin Production in Human Bronchial Smooth Muscle Cells.
Makita K, et al.
International Archives of Allergy and Immunology, 175(1-2), 26-35 (2018)

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