SAB4200117

抗 冠状病毒-1C（C 端） 兔抗

~1.5 mg/mL, affinity isolated antibody

• 同義詞: Anti-CORO1C, Anti-Coronin-1C (C-terminal region), Anti-Coronin-3 (mouse), Anti-HCRNN4
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~55 kDa
• 包裝: antibody small pack of 25 μL
• 濃度: ~1.5 mg/mL
• 技術: indirect immunofluorescence: 5-10 μg/mL using NIH3T3 cells; western blot: 1.5-3.0 μg/mL using A431 cell extract
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... CORO1C(23603) ; mouse ... Coro1c(23790) ; rat ... Coro1c(501841)

描述

一般說明

Coronin-1C (also known as CORO1C, Coronin-3, HCRNN4) belongs to the coronin family of tryptophan-aspartic acid (WD) 40 repeat-containing proteins. Coronin-1C is ubiquitously expressed and co-localizes with F-actin. In fibroblasts, CORO1C is localized both in the cytosol and in the submembrane cytoskeleton, especially at lamellipodia and membrane ruffles.

應用

Anti-Coronin-1C (C-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

生化／生理作用

Coronins appear to function primarily in association with the membrane cytoskeleton through interaction with F-actin and the actin-related protein (Arp2/3) complex. They localize to submembrane areas and regulate cell motility and cytoskeletal rearrangement. important in cytokinesis, cell motility, endocytosis, axonal growth, wound healing and signal transduction by altering actin dynamics. Coronin-1C is abundantly expressed in the central nervous system (CNS) during embryogenesis and first postnatal stages and in primary oligodendrocytes.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable