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Key Documents

SAB3501039

Sigma-Aldrich

Anti-N-RAS antibody produced in rabbit

affinity isolated antibody

同義詞:

Anti-ALPS4, Anti-CMNS, Anti-KRAS, Anti-N-ras, Anti-NCMS, Anti-NRAS1, Anti-NS6

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

predicted mol wt 22 kDa

物種活性

human, mouse, rat

濃度

1 mg/mL

技術

ELISA: suitable
immunoblotting: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... NRAS(4893)

免疫原

Antibody was raised against a 15 amino acid peptide near the carboxy terminus of human N-RAS.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

聯結

The action of this antibody can be blocked using blocking peptide SBP3501039.

外觀

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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S Rodenhuis
Seminars in cancer biology, 3(4), 241-247 (1992-08-01)
Mutational activation of ras oncogenes is frequently encountered in human tumors. For unexplained reasons, K-ras mutations are predominantly found in pancreatic cancer, colorectal cancer and adeno-carcinoma of the lung, N-ras is predominantly found in a subset of acute leukemias and
S Malaney et al.
Journal of mammary gland biology and neoplasia, 6(1), 101-113 (2001-07-27)
The Ras superfamily of GTPases act as important regulatory switches to co-ordinate extracellular stimuli with activation of intracellular signaling pathways and appropriate biological responses. The Ras branch of this superfamily includes H-, K- and N-Ras, which are commonly mutated in
John T Swarthout et al.
The Journal of biological chemistry, 280(35), 31141-31148 (2005-07-08)
Covalent lipid modifications mediate the membrane attachment and biological activity of Ras proteins. All Ras isoforms are farnesylated and carboxyl-methylated at the terminal cysteine; H-Ras and N-Ras are further modified by palmitoylation. Yeast Ras is palmitoylated by the DHHC cysteine-rich
Annette Ehrhardt et al.
Experimental hematology, 30(10), 1089-1106 (2002-10-18)
Many members of the Ras superfamily of GTPases have been implicated in the regulation of hematopoietic cells, with roles in growth, survival, differentiation, cytokine production, chemotaxis, vesicle-trafficking, and phagocytosis. The well-known p21 Ras proteins H-Ras, N-Ras, K-Ras 4A, and K-Ras

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