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Merck
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重要文件

SAB2501686

Sigma-Aldrich

Anti-NOX1 antibody produced in goat

affinity isolated antibody, buffered aqueous solution

同義詞:

GP91-2, MOX1, NADPH oxidase 1, NOH-1

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About This Item

分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

goat

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

mouse, human, bovine, canine

技術

indirect ELISA: suitable
western blot: suitable

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... NOX1(27035)

一般說明

NADPH oxidase 1 (NOX1) is encoded by the gene mapped to human chromosome Xq22.1. The protein belongs to the family of NADPH oxidases and is co-localized with caveolin in punctate patches on the surface and laterally on the cellular margins. NOX1 is mainly expressed in colon epithelium.

免疫原

Peptide with sequence C-DKATDIVTGLKQK, from the internal region of the protein sequence according toNP_008983.2; NP_39249.1

應用

Anti-NOX1 antibody produced in goat has been used for Western blotting.

生化/生理作用

NOX1 catalyzes the production of hydrogen peroxide (H2O2). Overexpression of the protein leads to the production of superoxide and H2O2 and triggers angiogenic switch, mediating vascularization and rapid expansion of the tumor. Elevated expression of NOX1 has been observed in the brain of Parkinson′s disease (PD) patients.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外觀

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Hyehun Choi et al.
Free radical biology & medicine, 101, 413-423 (2016-11-14)
Leucine Rich Repeat Containing 8A (LRRC8A) is a required component of volume-regulated anion channels (VRACs). In vascular smooth muscle cells, tumor necrosis factor-α (TNFα) activates VRAC via type 1 TNFα receptors (TNFR1), and this requires superoxide (O2•-) production by NADPH
Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning
Shuxia Jiang
Cardiovascular Research, 102(1) (2014)
NADPH oxidases in Parkinson?s disease: a systematic review
Karim Belarbi
Molecular Neurobiology, 12(84) (2017)
Distinct Subcellular Localizations of Nox1 and Nox4 in Vascular Smooth Muscle Cells
Lula L
Arteriosclerosis, Thrombosis, and Vascular Biology, 24(4) (2004)
Shuxia Jiang et al.
Cardiovascular research, 102(1), 79-87 (2014-02-07)
Ischaemic preconditioning (IPC) is an adaptive mechanism that renders the myocardium resistant to injury from subsequent hypoxia. Although reactive oxygen species (ROS) contribute to both the early and late phases of IPC, their enzymatic source and associated signalling events have

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