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Merck
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重要文件

S4944

Sigma-Aldrich

Monoclonal Anti-Sonic Hedgehog (N-terminal) antibody produced in rat

clone 171018, purified immunoglobulin, lyophilized powder

同義詞:

Anti-Shh

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About This Item

MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.41

生物源

rat

品質等級

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

171018, monoclonal

形狀

lyophilized powder

物種活性

human, mouse

技術

capture ELISA: suitable
immunohistochemistry (frozen sections): 25 μg/mL using mouse embryo
neutralization: suitable
western blot: 1-2 μg/test

同型

IgG2a

UniProt登錄號

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... SHH(6469)
mouse ... Shh(20423)

免疫原

purified, E. coli-derived, recombinant mouse sonic hedgehog N-terminal peptide (amino acids 25-198).

生化/生理作用

Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, gamma catenin, myc and other transcription factors. The Hh family members have multiple roles as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during development of limb and axon guidance factors during the development of brain and nervous system.

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Raffaella Bonavita et al.
Biology open, 7(7) (2018-05-23)
In humans, the sacrum forms an important component of the pelvic arch, and it transfers the weight of the body to the lower limbs. The sacrum is formed by collapse of the intervertebral discs (IVDs) between the five sacral vertebrae
Chitra Lekha Dahia et al.
PloS one, 7(4), e35944-e35944 (2012-05-05)
Intervertebral discs (IVD) are essential components of the vertebral column. They maintain separation, and provide shock absorbing buffers, between adjacent vertebrae, while also allowing movements between them. Each IVD consists of a central semi-liquid nucleus pulposus (NP) surrounded by a
Alessia Omenetti et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(3), G595-G598 (2008-01-26)
Hedgehog (Hh) signaling modulates tissue remodeling by controlling the fate of Hh-responsive cells. Healthy adult livers exhibit little Hh activity. However, cells involved in adult liver repair, including myofibroblasts and progenitors, are capable of producing and responding to Hh ligands.
Wenwu Dong et al.
International journal of clinical and experimental medicine, 7(7), 1786-1793 (2014-08-16)
The sonic hedgehog (SHH) and STAT3 signaling pathways play important roles during carcinogenesis with possible interaction. To determine the association of the activation of SHH signaling pathway and STAT3 pathway in carcinogenesis of human papillary thyroid cancer (PTC), we examined
Shohreh F Farzan et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(4), G844-G849 (2008-02-02)
The Hedgehog (Hh) family of secreted proteins is necessary for aspects of the development and maintenance of the gastrointestinal tract. Hh is thought to function as a morphogen, a mitogen, a cell survival factor, and an axon guidance factor. Given

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