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S3672

Sigma-Aldrich

[Sar9, Met(O2)11]-Substance P

≥95% (HPLC)

同義詞:

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O2]-NH2

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About This Item

經驗公式（希爾表示法）:
C64H100N18O15S
CAS號碼:
110880-55-2
分子量：:
1393.66
MDL號碼:
MFCD00076787
分類程式碼代碼:
12352209
PubChem物質ID:
24899567
NACRES:
NA.32

化驗

≥95% (HPLC)

儲存溫度

−20°C

SMILES 字串

CC(C)CC(NC(=O)CN(C)C(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(N)CCCNC(N)=N)C(=O)NC(CCS(C)(=O)=O)C(N)=O

InChI

1S/C64H100N18O15S/c1-38(2)34-46(57(89)74-42(54(69)86)28-33-98(4,96)97)73-53(85)37-80(3)62(94)48(36-40-18-9-6-10-19-40)79-58(90)47(35-39-16-7-5-8-17-39)78-56(88)43(24-26-51(67)83)75-55(87)44(25-27-52(68)84)76-59(91)50-23-15-32-82(50)63(95)45(21-11-12-29-65)77-60(92)49-22-14-31-81(49)61(93)41(66)20-13-30-72-64(70)71/h5-10,16-19,38,41-50H,11-15,20-37,65-66H2,1-4H3,(H2,67,83)(H2,68,84)(H2,69,86)(H,73,85)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,88)(H,79,90)(H4,70,71,72)

InChI 密鑰

OUPXSLGGCPUZJJ-UHFFFAOYSA-N

基因資訊

human ... TACR1(6869)
mouse ... TACR1(21336)
rat ... TACR1(24807)

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Amino Acid Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met[O]2-NH2

生化／生理作用

Highly selective NK-1 receptor agonist.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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Frank Cloutier et al.
British journal of pharmacology, 148(1), 25-38 (2006-02-24)
1 Effects of intrathecally (i.t.) injected tachykinin NK-1 and -3 receptor agonists and antagonists were measured on mean arterial blood pressure (MAP) and heart rate (HR) in awake unrestrained spontaneously hypertensive rats (SHR,15-week-old) and age-matched Wistar Kyoto rats (WKY). Quantitative
Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist[SAR9MET(O2)11]substance.
Yip, J., et al.
P. Neuroscience, 94, 663-673 (1999)
Wen-Ling Chen et al.
Biochemical and biophysical research communications, 339(1), 132-136 (2005-11-23)
Neurokinin-1 receptor (NK-1) plays an important role in nociception. The present study was to explore whether activation of peripheral NK-1 receptor, especially expressed on primary sensory afferents, could induce hyperalgesia and sensitize C-type sensory afferents. (1) Intraplantar administration of NK-1
Qiao-Ling Cui et al.
The European journal of neuroscience, 26(7), 1853-1861 (2007-09-18)
Substance P is a member of the neurokinin family. Previous studies have reported the existence of substance P and its high-affinity receptor, neurokinin-1 receptor, in globus pallidus. Employing in vivo extracellular recording combined with behavioural tests, the effects of substance
Angelina Y Fong et al.
The Journal of physiology, 575(Pt 3), 869-885 (2006-07-11)
In the present study, we examined the role of the neurokinin-1 receptor (NK1R) in the modulation of respiratory rhythm in a functionally identified bradypnoeic region of the ventral respiratory group (VRG) in the in situ arterially perfused juvenile rat preparation.
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