N6383

神经降压素

≥90% (HPLC)

• 經驗公式（希爾表示法）: C₇₈H₁₂₁N₂₁O₂₀
• CAS號碼: 58889-67-1
• 分子量：: 1672.92
• MDL號碼: MFCD00076678
• 分類程式碼代碼: 51111800
• PubChem物質ID: 329818664
• NACRES: NA.32

屬性

• 品質等級: 200
• 化驗: ≥90% (HPLC)
• 形狀: powder
• UniProt登錄號: P30990
• 儲存溫度: −20°C
• SMILES 字串: CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]5CCC(=O)N5)C(=O)N[C@@H](CC(C)C)C(O)=O
• InChI: 1S/C78H121N21O20/c1-7-43(6)63(73(115)96-57(76(118)119)37-42(4)5)97-70(112)55(39-45-21-25-47(101)26-22-45)95-72(114)59-18-13-35-99(59)75(117)52(16-11-33-86-78(83)84)90-64(106)48(15-10-32-85-77(81)82)89-71(113)58-17-12-34-98(58)74(116)51(14-8-9-31-79)91-69(111)56(40-60(80)102)94-66(108)50(28-30-62(104)105)88-68(110)54(38-44-19-23-46(100)24-20-44)93-67(109)53(36-41(2)3)92-65(107)49-27-29-61(103)87-49/h19-26,41-43,48-59,63,100-101H,7-18,27-40,79H2,1-6H3,(H2,80,102)(H,87,103)(H,88,110)(H,89,113)(H,90,106)(H,91,111)(H,92,107)(H,93,109)(H,94,108)(H,95,114)(H,96,115)(H,97,112)(H,104,105)(H,118,119)(H4,81,82,85)(H4,83,84,86)/t43-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,63-/m0/s1
• InChI 密鑰: PCJGZPGTCUMMOT-ISULXFBGSA-N
• 基因資訊: human ... NTS(4922)

描述

Amino Acid Sequence

Glp-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu

一般說明

Neurotensin (NT) is encoded by the gene mapped to human chromosome 12q21.31. The encoded protein is a tridecapeptide with pGlu–Leu–Tyr–Glu–Asn–Lys–Pro–Arg–Arg–Pro–Tyr–Ile–Leu–COOH amino acid sequence. NT is widely distributed in the gastrointestinal (GI) tract and central nervous system (CNS), but at high levels in hypothalamus, amygdala and nucleus accumbens as well as at low levels in peripheral blood.

應用

Neurotensin has been used as an external calibration reagent in spectrum calibration. It has also been used to evaluate the performance of online capillary electrophoresis to matrix-assisted laser desorption ionization (CE-MALDI).

Neurotensin has been used in apoptosis/ cell death assay and is used in:

• matrix-assisted laser desorption/ionisation-time of flight (MALDI-TOF) mass spectrometry analysis

生化／生理作用

Neurotensin (NT) acts as an inducer for analgesia, hypothermia and hyperglycemia, and is an inhibitor of gastric motility. Plasma NT levels are high in children with Prader–Willi syndrome (PWS). NT secreted from small cell lung cancer cells might have a regulatory action in this disease. It has been implicated in regulation of gastric system and inflammatory processes in the lung. In addition, NT also regulates immune response by stimulating cytokine release and chemotaxis on interaction with leukocytes, peritoneal mast cells and dendritic cells. NT present in gastrointestinal (GI) tract plays a vital role in various processes such as stimulation of pancreatic and biliary secretion and enhances growth of various normal tissues. It is involved downstream of Wnt/β-catenin signaling pathway and stimulates the growth of neuroendocrine tumor cells.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)