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Merck
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重要文件

S0577

Sigma-Aldrich

Streptokinase C from Streptococcus sp.

lyophilized solid, ≥3,500 unit/mg solid

同義詞:

Streptokinase

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About This Item

酶委員會編號:
分類程式碼代碼:
12352204
NACRES:
NA.54

生物源

bacterial (Streptococcus sp.)

品質等級

重組細胞

expressed in E. coli

化驗

40—60% protein (biuret)

形狀

lyophilized solid

比活性

≥3,500 unit/mg solid

顏色

off-white to light yellow

應用

life science and biopharma

儲存溫度

−20°C

基因資訊

Streptococcus pyogenes ... SKC(134997)

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一般說明

Research area: Cell Signaling

Streptokinase is an extracellular enzyme, a single-chain polypeptide produced by several strains of β-hemolytic Streptococci. It is composed of multiple structural domains like α-, β-, and γ-domains that are involved in various functions.

應用

Streptokinase C from Streptococcus sp. has been used to quantitate the survival of Staphylococcus aureus in whole human blood.

生化/生理作用

Streptokinase shows fibrinolytic activity by triggering the circulatory plasminogen either via a fibrin-dependent or fibrin-independent mechanism. Streptokinase has been studied majorly in terms of its therapeutic efficacy and treating myocardial infarction to dissolve clots.

單位定義

One unit will liquify a standard clot of fibrinogen, plasminogen, and thrombin at pH 7.5 at 37 °C in 10 min.

外觀

Lyophilized powder containing approx. 50% bovine serum albumin (total protein by biuret) with sodium glutamate.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Kerstin Steiner et al.
Infection and immunity, 70(7), 3627-3636 (2002-06-18)
Synthesis of the plasminogen activator streptokinase (SK) by group A streptococci (GAS) has recently been shown to be subject to control by two two-component regulators, covRS (or csrRS) and fasBCA. In independent studies, response regulator CovR proved to act as

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