PZ0369
PF-04217329
≥98% (HPLC)
同義詞:
2-[3-[[[[4-(1H-Pyrazol-1-yl)phenyl]methyl](3-pyridinylsulfonyl)amino]methyl]phenoxy]-acetic acid 1-methylethyl ester, Isopropyl 2-[3-[[[[4-(1H-pyrazol-1-yl)phenyl]methyl](pyridin-3-ylsulfonyl)amino]methyl]phenoxy]acetate, PF 04217329, Taprenepag isopropyl
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About This Item
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
room temp
SMILES 字串
O=S(N(CC1=CC=C(N2N=CC=C2)C=C1)CC3=CC=CC(OCC(OC(C)C)=O)=C3)(C4=CC=CN=C4)=O
InChI
1S/C27H28N4O5S/c1-21(2)36-27(32)20-35-25-7-3-6-23(16-25)19-30(37(33,34)26-8-4-13-28-17-26)18-22-9-11-24(12-10-22)31-15-5-14-29-31/h3-17,21H,18-20H2,1-2H3
InChI 密鑰
NVPXUFQLKWKBHK-UHFFFAOYSA-N
生化／生理作用
PF-04217329 is a selective and potent prostaglandin EP2 receptor agonist. PF-04217329 is an ocular bioavailable isopropyl ester prodrug of CP-544326 (active acid metabolite).
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Ganesh Prasanna et al.
Experimental eye research, 93(3), 256-264 (2011-03-08)
Better control of intraocular pressure (IOP) is the most effective way to preserve visual field function in glaucomatous patients. While prostaglandin FP analogs are leading the therapeutic intervention for glaucoma, new target classes also are being identified with new lead
Gina M Yanochko et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 30(5), 429-439 (2014-04-12)
Taprenepag isopropyl is an EP2 receptor agonist that is in development for the treatment of glaucoma. Iritis, photophobia, and increased corneal thickness observed in a Phase 2 clinical trial with taprenepag isopropyl were not previously observed in topical ocular toxicity
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