推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to off-white
溶解度
DMSO: >10 mg/mL
儲存溫度
room temp
SMILES 字串
NS(=O)(=O)c1ccc(cc1)N2CCN(CC[C@@H]3OCCc4ccccc34)CC2
InChI
1S/C21H27N3O3S/c22-28(25,26)19-7-5-18(6-8-19)24-14-12-23(13-15-24)11-9-21-20-4-2-1-3-17(20)10-16-27-21/h1-8,21H,9-16H2,(H2,22,25,26)/t21-/m0/s1
InChI 密鑰
WNUQCGWXPNGORO-NRFANRHFSA-N
生化／生理作用
Sonepiprazole (U-101387) is a selective D4 dopamine antagonist.
Sonepiprazole (U-101387) is a selective D4 dopamine antagonist. Ki = 10 nM for the dopamine D4.2 receptor.
特點和優勢
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Mark H Corrigan et al.
Biological psychiatry, 55(5), 445-451 (2004-03-17)
Selective localization of dopamine D(4) receptors in the prefrontal cortex and preferential affinity of clozapine for the dopamine D(4) receptor over the D(2) receptor led to the hypothesis that the superior efficacy of clozapine may be mediated via blockade of
A F Arnsten et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 23(4), 405-410 (2000-09-16)
Stress exposure impairs the cognitive functioning of the prefrontal cortex (PFC). Previous research has examined the dopamine (DA) D1 receptor mechanisms underlying this response. The current study performed a preliminary examination of the role of D4 receptor mechanisms by determining
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
R E TenBrink et al.
Journal of medicinal chemistry, 39(13), 2435-2437 (1996-06-21)
K Noda-Saita et al.
Biochemical and biophysical research communications, 255(2), 367-370 (1999-03-02)
Dopamine D4-like binding sites are abundant in human cerebral cortex as detected by [3H]nemonapride. The extremely low density of D4 mRNA in human cerebral cortex is inconsistent with the high amount of D4-like binding sites. To investigate the nature of
Peter Hertel et al.
European journal of pharmacology, 573(1-3), 148-160 (2007-08-11)
The present study describes the pharmacological profile of the putative antipsychotic drug Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole). The in vitro receptor profile of Lu 35-138 revealed high affinity (K(i)=5 nM) and competitive antagonism (K(b)=8 nM) at dopamine D(4) receptors combined with potent
文章
Sigma-Aldrich offers many products related to dopamine receptors for your research needs.
We offer many products related to dopamine receptors for your research needs.
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