推薦產品
生物源
synthetic (organic)
化驗
≥98% (TLC)
形狀
liquid
濃度
10 mg/mL in ethanol
儲存溫度
−20°C
SMILES 字串
CCCCCCCCCCCCCCCC(=O)C(F)(F)F
InChI
1S/C17H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(21)17(18,19)20/h2-15H2,1H3
InChI 密鑰
MAHYXYTYTLCTQD-UHFFFAOYSA-N
生化／生理作用
Reversible inhibitor of calcium-dependent phospholipase A2 (IC50 = 3.8 μM). Unlike other PLA2 inhibitors studied, PACOCF3 at 50 μM induced an increase in intracellular [Ca2+], and at 10 μM, enhanced calcium-ion influx induced by ATP and bradykinin.
訊號詞
Danger
危險聲明
危險分類
Eye Irrit. 2 - Flam. Liq. 2
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
57.2 °F - closed cup
閃點（°C）
14.0 °C - closed cup
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Dual action of palmitoyl trifluoromethyl ketone (PACOCF3) on Ca2+ signaling: activation of extracellular Ca2+ influx and alteration of ATP- and bradykinin-induced Ca2+ responses in Madin Darby canine kidney cells
Jan, C.R., et al.
Toxicology, 74, 447-451 (2000)
Oscar Yanes et al.
Nature chemical biology, 6(6), 411-417 (2010-05-04)
Metabolites offer an important unexplored complementary approach to understanding the pluripotency of stem cells. Using MS-based metabolomics, we show that embryonic stem cells are characterized by abundant metabolites with highly unsaturated structures whose levels decrease upon differentiation. By monitoring the
Y C Lio et al.
Biochimica et biophysica acta, 1302(1), 55-60 (1996-07-12)
Methyl arachidonyl fluorophosphonate (MAFP) has been recently reported to be a selective, active-site directed, irreversible inhibitor of the Group IV 85 kDa cytosolic phospholipase A2 (cPLA2). We have now shown that this compound also potently inhibits the Ca(2+)-independent cytosolic phospholipase
Susann Liebscher et al.
PLoS pathogens, 14(4), e1007029-e1007029 (2018-05-01)
Positive-sense RNA virus intracellular replication is intimately associated with membrane platforms that are derived from host organelles and comprised of distinct lipid composition. For flaviviruses, such as West Nile virus strain Kunjin virus (WNVKUN) we have observed that these membrane
E J Ackermann et al.
The Journal of biological chemistry, 270(1), 445-450 (1995-01-06)
A novel Ca(2+)-independent phospholipase A2 (PLA2) has recently been purified from the murine macrophage-like cell line P388D1 (Ackermann, E. J., Kempner, E. S., and Dennis, E. A. (1994) J. Biol. Chem. 269, 9227-9233). This enzyme is now shown to be
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