跳轉至內容
Merck
全部照片(4)

重要文件

P8386

Sigma-Aldrich

保泰松

同義詞:

4-丁基-1,2-二苯基-3,5-吡唑烷二酮

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C19H20N2O2
CAS號碼:
分子量::
308.37
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

化驗

≥98% (HPLC)

形狀

powder

mp

106-108 °C (lit.)

溶解度

ethanol: 50 mg/mL, clear, colorless to light yellow

SMILES 字串

CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3

InChI

1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3

InChI 密鑰

VYMDGNCVAMGZFE-UHFFFAOYSA-N

尋找類似的產品? 前往 產品比較指南

應用

保泰松已被用于:
  • 在转基因斑马鱼(LiPan)肝毒素测定中用作肝毒素
  • 在高效液相色谱-紫外(HPLC-UV)中用作标准品
  • 在鸡′蛋绒毛尿囊膜试验(HET-CAM试验)中用作抗炎化合物

生化/生理作用

保泰松是一种肝毒素,可与血浆蛋白结合。它可用于治疗马的炎症。保泰松具有治疗强直性脊柱炎的潜力。它可通过诱导肌盲样蛋白1(MBNL1)的表达而具有治疗I型强直性肌营养不良(DM1)的潜力。它还有利于骨骼肌中肌肉氯离子通道的表达。

基底

非甾体抗炎化合物;环氧合酶抑制剂,也是环氧合酶过氧化的底物。

象形圖

Skull and crossbones

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


從最近期的版本中選擇一個:

分析證明 (COA)

Lot/Batch Number

未看到正確版本?

如果您需要一個特定的版本,您可以透過批號來尋找特定憑證。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy
Chen G, et al.
Scientific Reports, 6, 25317-25317 (2016)
Amit Verma et al.
European journal of medicinal chemistry, 43(5), 897-905 (2007-09-18)
The broad and potent activity of 4-thiazolidinones has established it as one of the biologically important scaffolds. This article is an effort to highlight the importance of the 4-thiazolidinones in the present context and promise they hold for the future.
Phenylbutazone purity challenge
McRae G, et al.
Analytical and Bioanalytical Chemistry, 408(12), 3051-3053 (2016)
J H Foreman et al.
Equine veterinary journal. Supplement, (38)(38), 601-605 (2011-05-27)
Objective blinded efficacy data during exercise are lacking on the use of single-dose i.v. nonsteroidal anti-inflammatory drugs (NSAIDs) before, during and after exercise. Single i.v. doses of either phenylbutazone (PBZ) or flunixin meglumine (FM) would prove more efficacious than negative
J H Foreman et al.
Equine veterinary journal. Supplement, (40)(40), 12-17 (2011-12-07)
Using an adjustable heart bar shoe model of foot pain, the objective of this study was to test the hypothesis that the combined use of phenylbutazone (PBZ) and flunixin meglumine (FM) would prove more efficacious in alleviating lameness than either

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務