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Merck
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重要文件

P4623

Sigma-Aldrich

Anti-phospho-Interferon-α Receptor Type I (pSer535/pSer539) Subunit 1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

同義詞:

Anti-phospho-IFNα Receptor Type I (pSer535/pSer539) Subunit 1, Anti-phospho-IFNARI

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.46

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

rat, mouse, bovine, human

技術

western blot: 1:1,000 using using FLAG® immunoprecipitates from HEK 293 cells transfected with Mock, IFNAR1 wild type, or IFNAR1 S535A and S539A mutants

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

phosphorylation (pSer535/pSer539)

基因資訊

human ... IFNAR1(3454)
mouse ... Ifnar1(15975)
rat ... Ifnar1(288264)

免疫原

synthetic phosphopeptide corresponding to the amino acid residues surrounding the human phospho-interferon-α receptor type I (pSer535/pSer539) subunit 1.

生化/生理作用

Type I interferons (IFNα, IFNβ and IFNω) are pleotropic cytokines that mediate their cellular activities by binding to specific Type I IFN receptors. The functions of IFNα/ IFNα Receptor Type I axis include antiproliferative, antiviral and immunomodulatory activities.

外觀

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.

法律資訊

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Interferons alpha and beta as immune regulators--a new look.
C A Biron
Immunity, 14(6), 661-664 (2001-06-23)
P Domanski et al.
Cytokine & growth factor reviews, 7(2), 143-151 (1996-08-01)
The type-I interferon receptor is a multisubunit receptor of the cytokine receptor superfamily. The production of specific monoclonal antibodies against the receptor and the cloning of different receptor subunits have contributed to understanding the type-I interferon receptor structure and function.
L C Platanias et al.
The Journal of biological chemistry, 271(39), 23630-23633 (1996-09-27)
All Type I interferons (IFNalpha, IFNbeta, IFNomega) bind to the Type I IFN receptor (IFNR) and elicit a common set of signaling events, including activation of the Jak/Stat and IRS pathways. However, IFNbeta selectively induces the association of the alpha

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