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L9125

Sigma-Aldrich

L -亮氨酸- p -硝基苯胺

leucine aminopeptidase substrate, chromogenic, ≥98% (TLC), powder

同義詞:

L-亮氨酸-4-硝基苯胺

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About This Item

經驗公式(希爾表示法):
C12H17N3O3
CAS號碼:
分子量::
251.28
Beilstein:
2218433
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.32

product name

L -亮氨酸- p -硝基苯胺, leucine aminopeptidase substrate

品質等級

化驗

≥98% (TLC)

形狀

powder

溶解度

ethanol: 50 mg/mL

儲存溫度

2-8°C

SMILES 字串

CC(C)C[C@H](N)C(=O)Nc1ccc(cc1)[N+]([O-])=O

InChI

1S/C12H17N3O3/c1-8(2)7-11(13)12(16)14-9-3-5-10(6-4-9)15(17)18/h3-6,8,11H,7,13H2,1-2H3,(H,14,16)/t11-/m0/s1

InChI 密鑰

AXZJHDNQDSVIDR-NSHDSACASA-N

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應用

L-亮氨酸-p-硝基苯胺用为底物,可用于:
  • 测定虹鳟幼鱼肠道亮氨酸氨基肽酶的活性(虹鳟
  • 胰岛素调节氨肽酶的抑制分析
  • 测定外肽酶的活性

基底

用于比色法测定亮氨酸氨肽酶的底物。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


分析證明 (COA)

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Identification of drug-like inhibitors of insulin-regulated aminopeptidase through small-molecule screening
Engen K, et al.
Assay and Drug Development Technologies, 14(3), 180-193 (2016)
W Bawab et al.
The Biochemical journal, 286 ( Pt 3), 967-975 (1992-09-15)
Aminopeptidase activities were identified in extracts of kidney, ovotestis, head ganglia, heart and haemolymph of Aplysia californica. These enzyme preparations hydrolysed [3H][Leu]enkephalin at the Try-1-Gly-2 bond as determined by h.p.l.c. analysis of cleavage products. In all these tissues, enkephalin-degrading aminopeptidase
K W Garren et al.
Pharmaceutical research, 6(11), 966-970 (1989-11-01)
The simultaneous diffusion and metabolism of the D- and L-isomers of the aminopeptidase substrate, leucine-p-nitroanilide (LPNA), were examined in vitro in the hamster cheek pouch. L-LPNA was completely hydrolyzed during diffusion across the cheek pouch, whereas D-LPNA crossed the cheek
Effects of fish meal replacement with meat and bone meal using garlic (Allium sativum) powder on growth, feeding, digestive enzymes and apparent digestibility of nutrients and fatty acids in juvenile rainbow trout (Oncorhynchus mykiss Walbaum, 1792)
Esmaeili M, et al.
Aquaculture Nutrition, 23(6), 1225-1234 (2017)
I M Cesari et al.
The Journal of parasitology, 69(2), 280-284 (1983-04-01)
An aminopeptidase activity capable of hydrolysing leucine 4-nitroanilide and alanine 4-nitroanilide at pH 7.0 was detected in saponin-CaCl2 extracts and homogenates of adult Schistosoma mansoni. The extracts were also capable of acting on synthetic dipeptides at the same pH, preferentially

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