推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
顏色
white to yellow
溶解度
H2O: 22 mg/mL
SMILES 字串
Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1
InChI
1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2
InChI 密鑰
YCALIZUKAFUQCH-UHFFFAOYSA-N
應用
PJ-34盐酸盐水合物用于：
- 作为聚（ADP-核糖）聚合酶(PARP)抑制剂1，测试PAPR1对大鼠神经性疼痛的作用
- 作为蛋白质提取缓冲液的组分，可视化各种细胞样本中中PARylated蛋白质的高分子量涂片
- 作为小鼠MLE-12上皮细胞系的PARP抑制剂
生化／生理作用
PJ-34是一种原型聚（ADP-核糖）聚合酶1 (PARP-1)抑制剂。
PJ-34是一种强效聚(ADP-核糖)聚合酶（PARP）抑制剂。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
G E Abdelkarim et al.
International journal of molecular medicine, 7(3), 255-260 (2001-02-17)
Focal cerebral ischemia activates the nuclear protein poly(ADP-ribose) polymerase (PARP) by single DNA strand breaks which leads to energy depletion and cell necrosis. Deletion or inhibition of PARP protects against ischemic brain injury. Here we examined the neuroprotective effect of
Yan Gao et al.
Brain, behavior, and immunity, 88, 482-496 (2020-04-14)
Emerging evidence has implicated poly-(ADP-ribose) polymerase 1 (PARP-1), a transcriptional coregulator, in a variety of inflammatory diseases. In the current study, the role of PARP-1 in neuropathic pain and the underlying mechanisms were investigated. Neuropathic pain was determined by assessing
Garcia Soriano F et al.
Nature medicine, 7(1), 108-113 (2001-01-03)
Diabetic patients frequently suffer from retinopathy, nephropathy, neuropathy and accelerated atherosclerosis. The loss of endothelial function precedes these vascular alterations. Here we report that activation of poly(ADP-ribose) polymerase (PARP) is an important factor in the pathogenesis of endothelial dysfunction in
Hai-yan Li et al.
Acta pharmacologica Sinica, 35(4), 496-503 (2014-03-19)
Daidzein (4',7-dihydroxyisoflavone) is an isoflavone exiting in many herbs that has shown anti-inflammation activity. The aim of this study was to investigate the mechanism underlying its anti-inflammatory action in murine lung epithelial cells. C57BL/6 mice were intranasally exposed to TNF-α
Mohamad El Amki et al.
Molecular neurobiology, 55(12), 9156-9168 (2018-04-14)
Benefits from thrombolysis with recombinant tissue plasminogen activator (rt-PA) after ischemic stroke remain limited due to a narrow therapeutic window, low reperfusion rates, and increased risk of hemorrhagic transformations (HT). Experimental data showed that rt-PA enhances the post-ischemic activation of
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