P1784

己酮可可碱

solid

• 同義詞: 3,7-Dimethyl-1-(5-oxohexyl)xanthine, Trental
• 經驗公式（希爾表示法）: C₁₃H₁₈N₄O₃
• CAS號碼: 6493-05-6
• 分子量：: 278.31
• EC號碼: 229-374-5
• MDL號碼: MFCD00063379
• 分類程式碼代碼: 41106305
• PubChem物質ID: 24278190
• NACRES: NA.77

屬性

• 形狀: solid
• 品質等級: 100
• 顏色: white
• 溶解度: H₂O: ≥43 mg/mL, colorless to almost colorless
• 起源: Sanofi Aventis
• SMILES 字串: CN1C=NC2C1C(=O)N(CCCCC(C)=O)C(=O)N2C
• InChI: 1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8,10-11H,4-7H2,1-3H3
• InChI 密鑰: MQGNNJQTNFHNHK-UHFFFAOYSA-N
• 基因資訊: human ... ADORA2B(136) , LITAF(9516) , PDE4B(5142) , TNF(7124) ; rat ... Tnf(24835)

描述

應用

Pentoxifylline has been used:

• used in the combinatorial treatment with itraconazole for paracoccidioidomycosis (PCM)
• to treat harvested sperms to check the effect of ′pentoxifylline exposed sperms′ in the contribution of embryonic growth
• to intrathecally inject female and male mice to investigate whether astrocytes and microglia could be causally involved in the maintenance of pain-like behaviour

生化／生理作用

Pentoxifylline (PTX) is considered as a nonspecific phosphodiesterase inhibitor. It possesses rheologic properties. Pentoxifylline is used to treat peripheral vascular disease. It has the ability to block the phosphorylation of I kappa B-alpha (IĸBα) in serines 32 and 36.

Phosphodiesterase inhibitor; inhibits synthesis of tumor necrosis factor α (TNF-α).

特點和優勢

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Histamine Synthesis and Metabolism and Phosphodiesterases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H362
• 防範說明: P202 - P260 - P263 - P264 - P301 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Lact.
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves