P0358

抗-钾通道 K_v4.3 兔抗

affinity isolated antibody, lyophilized powder

• 同義詞: Anti-BRGDA9, Anti-KCND3L, Anti-KCND3S, Anti-KSHIVB, Anti-KV4.3, Anti-SCA19, Anti-SCA22
• MDL號碼: MFCD02097221
• 分類程式碼代碼: 12352203
• NACRES: NA.41
• 無性繁殖: polyclonal
• application: IHC (p); WB CL
• 物種活性: rat, human
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot (chemiluminescent): 1:200
• citations: 2

屬性

• 生物源: rabbit
• 品質等級: 100
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: lyophilized powder
• 物種活性: rat, human
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; western blot (chemiluminescent): 1:200
• UniProt登錄號: Q9UK17
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... KCND3(3752) ; rat ... Kcnd3(65195)

描述

一般說明

Potassium voltage-gated channel subfamily D member 3 (KCND3) gene codes for Kv4.3, an α-subunit of the I_to channel. It has seven exons and is mapped to the human chromosome 1p13.2. Kv4.3 is expressed in the brain and the heart. Anti-potassium channel Kv4.3 recognizes Kv4.3 protein in the rat by immunoblotting.

免疫原

synthetic peptide corresponding to amino acids 451-468 of rat or human potassium channel K_v4.3 (with additional N-terminal tyrosine and methionine replaced with norleucine).

應用

Anti-Potassium Channel Kv4.3 antibody produced in rabbit has been used in immunohistochemistry.

生化／生理作用

Potassium channels contribute to maintaining cell volume, neuronal excitability, and the secretion of transmitters, salt, and hormones. Potassium voltage-gated channel subfamily D member (Kv4.3) is involved in membrane repolarization in excitable cells. Kv4.3 may participate in the development of the cerebellum. It is capable of forming homo- or hetero-tetramers with the Shal subfamily channel members. KCND3 gene mutations result in Brugada syndrome and spinocerebellar ataxia type 22.

外觀

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H312 + H332,H412
• 防範說明: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable