O1877

赭曲霉毒素A

from Petromyces albertensis, ≥98% (HPLC), powder, mycotoxin

• 同義詞: N-[(3R)-(5-氯-8-羟基-3-甲基-1-氧代-7-异苯并二氢吡喃基)羰基]-L-苯丙氨酸
• 經驗公式（希爾表示法）: C₂₀H₁₈ClNO₆
• CAS號碼: 303-47-9
• 分子量：: 403.81
• Beilstein: 1301486
• MDL號碼: MFCD00078079
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24897954
• NACRES: NA.77

屬性

• 產品名稱: 赭曲霉毒素A, from Petromyces albertensis, ≥98% (HPLC)
• 生物源: Petromyces albertensis
• 品質等級: 300
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 雜質: Benzene, free
• 溶解度: ethanol: soluble
• 作用方式: enzyme | inhibits; protein synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: C[C@@H]1Cc2c(Cl)cc(c(O)c2C(=O)O1)C(=O)N[C@@H](Cc3ccccc3)C(O)=O
• InChI: 1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)/t10-,15+/m1/s1
• InChI 密鑰: RWQKHEORZBHNRI-BMIGLBTASA-N

描述

應用

Ochratoxin A has been used as a mycotoxin:

• to test its effect on metabolism and hypoxia in human embryonic kidney (HEK293) cells
• to test its cytotoxic effects in bovine mammary epithelial cells
• as a standard for gamma radiation studies with food products and in cytotoxic studies using Hep G2 cells

生化／生理作用

Ochratoxin A (OTA), a renal toxin, is produced majorly by Aspergillus and Penicillium fungal species. It is immunotoxic, teratogenic myelotoxic, and mutagenic. It effectively interrupts the intestinal barrier functions. OTA displays a long elimination half-life and stimulates the major inflammatory cytokines release.

Ochratoxin A is a mycotoxin found in food that is nephrotoxic and carcinogenic in the kidney and induces differentiation in cloned renal cell lines. Increases endoplasmic reticulum ATP-dependent Ca²⁺ pump activity.

準備報告

This product is also soluble in chloroform (9.80 - 10.20 mg/ml), methanol (10 mg/ml), ethanol (50 mM), and DMSO (100 mM).

安全資訊

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H300,H351
• 防範說明: P201 - P264 - P280 - P301 + P310 + P330 - P308 + P313 - P501
• 危險分類: Acute Tox. 2 Oral - Carc. 2
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges