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Merck
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Key Documents

N6803

Sigma-Aldrich

Nystatin water soluble

powder, suitable for cell culture

同義詞:

Nystatin Solution

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About This Item

分類程式碼代碼:
12352207
NACRES:
NA.76

product name

Nystatin water soluble, suitable for cell culture

生物源

synthetic

形狀

powder

分子量

1029.23 g/mol

技術

cell culture | mammalian: suitable

溶解度

100 mg/mL

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

Nystatin is a polyene, broad-spectrum antibiotic. It can modify the microstructure of lipid rafts and sequestrate cholesterol present on the cell membrane of eukaryotes. Thus, nystatin can modulate immune responses. This is carried out through cytokine signaling, activation of lymphocytes and pathogen recognition.
Molecular Formula: C51H84N2O19
Molecular Weight: 1029.23
Nystatin water soluble is a Nystatin derivate with fungistatic and fungicidal activity in resemblance to Nystatin. However, as opposed to the poor solubility of Nystatin the water soluble derivate can be dissolved in concentration of up to 100mg/ml. Nystatin binds to ergosterol which increases cell membrane permeability in sensitive fungi. Nystatin is mainly clinically active against Candida species. However, it is also reported to be effective against Aspergillus, Coccidioides immitis, Cryptococcus neoformans, Histoplasma capsulatum, Blastomyces dermatidis, and other yeasts and fungi. Nystatin has also been used to enrich mutants by negative selection in yeasts. The minimum inhibitory concentration (MIC) of Nystatin to Saccharomyces cerevisiae was reported to be 3μg/ml while for clinical isolates of Candida albicans the MIC was reported to be 4-16μg/ml.

其他說明

Technical data

  • Nystatin water soluble is a fully solubilized powder of Nystatin with potency of ≥2000 units/mg according to USP standard.
  • Nystatin water soluble is 0.2μm filtered and endotoxin free.
  • The suggest working concentration of Nystatin water soluble is 100 units/ml.
  • It is recommended to store solutions of Nystatin water soluble in the dark.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Water-Soluble Nystatin and Derivative
Aviran Amir, Michal Levin-Khalifa, and Tamar Dvash
ACS Medicinal Chemistry Letters, 182?187-182?187 (2022)
Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal candidiasis
Zhang X, et al.
BMC Microbiology, 18(1), 166-166 (2018)

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