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重要文件

M7273

Sigma-Aldrich

Anti-Microtubule-Associated Proteins (MAPs) antibody produced in rabbit

whole antiserum

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41
無性繁殖:
polyclonal
application:
WB
物種活性:
mammals
技術:
western blot: 1:200
citations:
11

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

whole antiserum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

包含

15 mM sodium azide

物種活性

mammals

技術

western blot: 1:200

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

一般說明

Microtubule-associated protein 2 (MAP2) is a neuronal protein. It belongs to the MAP2/Tau family. This gene is located to human chromosome 2q34-q35. MAP2 is present in neurons. MAP2 is the major microtubule-associated protein of brain tissue. There are two major classes of heat stable MAPs; two are similarly sized with apparent molecular weights of 280kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70kDa (MAP2c).

特異性

Reacts with the two major classes of heat stable MAPs (MAP2 and τ). Does not react with MAP1 or tubulin.

免疫原

heat stable MAPs prepared from bovine brain.

應用

Anti-Microtubule-Associated Proteins (MAPs) antibody produced in rabbit has been used in:
  • immunofluorescent labelling
  • immunohistochemistry
  • immunoprecipitation
  • immunofluorescence staining
  • western blotting

生化/生理作用

Microtubule-associated protein 2 (MAP2) interacts with microtubules to maintain the structure of dendrites. It plays a major role in supporting the actin cytoskeleton in spines, binding and nucleating filamentous actin (f-actin) to modulate spine morphology. Microtubules function as structural and mobility elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Dynamic Instability of Microtubules Assembled from Microtubule-Associated Protein-Free Tubulin: Neither Variability of Growth and Shortening Rates nor ?Rescue? Requires Microtubule-Associated Proteins
Billger MA, et al.
Biochemistry, 35(42), 13656-13663 (1996)
The MAP2/Tau family of microtubule-associated proteins
Dehmelt L, et al.
Genome Biology, 6(1), 1-10 (2005)
Increased Phosphorylation of Ca/Calmodulin-dependent Protein Kinase II and Its Endogenous Substrates in the Induction of Long Term Potentiation
Fukunaga K, et al.
Test, 270(11), 6119-6124 (1995)
Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons
Coughlan CM, et al.
Neuroscience, 97(3), 591-600 (2000)
J H Holstein et al.
British journal of pharmacology, 154(5), 1055-1062 (2008-05-06)
The immunosuppressive drug rapamycin (RAPA) prevents rejection in organ transplantation by inhibiting interleukin-2-stimulated T-cell division. Rapamycin has also been suggested to possess strong anti-angiogenic activities linked to a decrease in production of vascular endothelial growth factor (VEGF). Angiogenesis and VEGF

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