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Key Documents

M6034

Sigma-Aldrich

IgG2a, Lambda from murine myeloma

clone HOPC-1, purified immunoglobulin, buffered aqueous solution

同義詞:

Mouse IgG2a-λ

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.46

生物源

mouse

共軛

unconjugated

抗體表格

purified immunoglobulin

無性繁殖

HOPC-1, monoclonal

形狀

buffered aqueous solution

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

一般說明

An immunoglobulin has two heavy chain and two light chain connected by disulfide bond. It is a glycoprotein. Rat has five immunoglobulin classes- IgM, IgG, IgA, IgD and IgGE. Immunoglobulin G (IgG) is a major class of immunoglobulin. IgG has four subclasses- IgG1, IgG2a, IgG2b and IgG2c.
IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections
IgG2a, λ from murine myeloma specifically recognizes mouse IgG2a. Specificity of the mouse IgG2a, λ is determined by immunodiffusion and IEP techniques. The purified myeloma preparation is non-reactive with antisera to mouse IgA, IgM, IgG1, IgG2a, IgG2b and IgG3.

應用

IgG2a, Lambda from murine myeloma has been used to standardize the enzyme-linked immunosorbent assay (ELISA) assay.

生化/生理作用

Immunoglobulin G (IgG) mainly helps in immune defense. Immunoglobulin G (IgG) participates in hypersensitivity type II and type III reactions. It helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity.

外觀

Solution in 0.02 M Tris buffered saline, pH 8.0, containing 0.02% sodium azide

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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The Laboratory Rat (1998)
The Immunoglobulins: Structure and Function (1998)
Molecular Genetics of Immunoglobulin, 17 (1987)
A human immunoglobulin lambda locus is similarly well expressed in mice and humans
Popov AV, et al.
The Journal of Experimental Medicine, 189(10), 1611-1620 (1999)
A V Popov et al.
The Journal of experimental medicine, 189(10), 1611-1620 (1999-05-20)
Transgenic mice carrying a 380-kb region of the human immunoglobulin (Ig) lambda light (L) chain locus in germline configuration were created. The introduced translocus on a yeast artificial chromosome (YAC) accommodates the most proximal Iglambda variable region (V) gene cluster

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