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重要文件

M4949

Sigma-Aldrich

2'-C-甲基胞嘧啶核苷

≥95% (HPLC), powder

同義詞:

2′-C-Methyl Cytidine, NM107

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About This Item

經驗公式(希爾表示法):
C10H15N3O5
CAS號碼:
分子量::
257.24
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥95% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to off-white

溶解度

H2O: >20 mg/mL

儲存溫度

−20°C

SMILES 字串

C[C@@]1(O)[C@H](O)[C@@H](CO)O[C@H]1N2C=CC(N)=NC2=O

InChI

1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1

InChI 密鑰

PPUDLEUZKVJXSZ-VPCXQMTMSA-N

生化/生理作用

2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase. 2′-C-Methylcytidine was the first nucleoside NS5B inhibitor that showed clinical efficacy. 2′-C-Methylcytidine was found to be effective against the 17D vaccine strain of yellow fever virus YFV in cell culture.
2′-C-Methylcytidine is a potent inhibitor of the HCV NS5B RNA polymerase.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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Natalie E Netzler et al.
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Myungeun Lee et al.
Scientific reports, 7, 44676-44676 (2017-03-24)
Despite recent advances in curing chronic hepatitis C (CHC), the high economic burden to therapy, viral drug resistance, difficult to treat hepatitis C virus (HCV) genotypes and patient groups are still of concern. To address this unmet medical needs, we
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Pathogens and global health, 112(4), 210-226 (2018-05-11)
Alkhumra hemorrhagic fever virus (AHFV), a relatively new member of the Flaviviruses, was discovered in Saudi Arabia 23 years ago. AHFV is classified in the tick-borne encephalitis virus serocomplex, along with the Kyasanur forest disease virus (KFDV) and tick-borne encephalitis

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