M3536

霉酚酸

powder, suitable for cell culture, BioReagent

• 同義詞: 6-（1,3-二氢-7-羟基-5-甲氧基-4-甲基-1-氧代异苯并呋喃-6-基）-4-甲基-4-己酸, 6-（4-羟基-6-甲氧基-7-甲基-3-氧代-5-酞酰）-4-甲基-4-己烯酸, NSC 129185
• 經驗公式（希爾表示法）: C₁₇H₂₀O₆
• CAS號碼: 24280-93-1
• 分子量：: 320.34
• Beilstein: 1295848
• EC號碼: 246-119-3
• MDL號碼: MFCD00036814
• 分類程式碼代碼: 12352207
• PubChem物質ID: 24896854
• NACRES: NA.76

屬性

• 產品名稱: 霉酚酸, powder, BioReagent, suitable for cell culture
• 生物源: Penicillium brevicompactum
• 品質等級: 300
• 產品線: BioReagent
• 形狀: powder
• 技術: cell culture | mammalian: suitable
• 顏色: white to yellow-white
• mp: <143.0 °C
• 溶解度: methanol: 50 mg/mL
• 作用方式: enzyme | inhibits
• 儲存溫度: 2-8°C
• SMILES 字串: COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O
• InChI: 1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
• InChI 密鑰: HPNSFSBZBAHARI-RUDMXATFSA-N
• 基因資訊: human ... IMPDH1(3614) , IMPDH2(3615)

描述

應用

Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL.

生化／生理作用

作用方式：本品通过抑制细胞因子诱导的一氧化氮生成，抑制嘌呤核苷酸的早期生物合成，并作为 IMP 脱氢酶的特异性抑制剂发挥作用。

注意

As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.

準備報告

Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.

安全資訊

• 象形圖: GHS08,GHS07,GHS09
• 訊號詞: Danger
• 危險聲明: H302,H341,H360D,H372,H410
• 防範說明: P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral
• 標靶器官: Immune system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges