推薦產品
化驗
≥95% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
H2O: ≥10 mg/mL
DMSO: ≥20 mg/mL
儲存溫度
−20°C
SMILES 字串
CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
InChI
1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1
InChI 密鑰
SRQUTZJZABSZRQ-RQJHMYQMSA-N
應用
MB-3已被用作通用控制蛋白5 (GCN5)抑制剂：
- 研究其对核纤层蛋白A/C相关pY19-Cav-2-介导组蛋白H3乙酰化的影响
- 分析其对拟南芥幼苗生长的影响
- 研究其对颅面软骨细胞成熟的影响
生化／生理作用
MB-3可以修饰小鼠胚胎干细胞和酵母的基因表达。它通过与GCN5中的乙酰辅酶CoA口袋结合来抑制通用控制蛋白5(GCN5)的乙酰转移酶活性。
MB-3 是一种 Gcn5 HAT（组蛋白乙酰转移酶）抑制剂；具有抗炎、抗癌作用。
特點和優勢
这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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文章
Epigenetic modifications are thought to occur through two key interconnected processes—DNA methylation and the covalent modification of histones.
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