M2011

左旋溶肉瘤素

powder

• 同義詞: 4-[Bis(2-chloroethyl)amino]-L-phenylalanine, L-PAM, L-Phenylalanine mustard
• 經驗公式（希爾表示法）: C₁₃H₁₈Cl₂N₂O₂
• CAS號碼: 148-82-3
• 分子量：: 305.20
• Beilstein: 2816456
• EC號碼: 205-726-3
• MDL號碼: MFCD00057717
• 分類程式碼代碼: 12352207
• PubChem物質ID: 24278538
• NACRES: NA.32

屬性

• 形狀: powder
• 品質等級: 200
• 顏色: white
• SMILES 字串: N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(O)=O
• InChI: 1S/C13H18Cl2N2O2/c14-5-7-17(8-6-15)11-3-1-10(2-4-11)9-12(16)13(18)19/h1-4,12H,5-9,16H2,(H,18,19)/t12-/m0/s1
• InChI 密鑰: SGDBTWWWUNNDEQ-LBPRGKRZSA-N

描述

一般說明

Melphalan also known as L-phenylalanine mustard is an alkylating agent. It belongs to the class of nitrogen mustards, which act as chemotherapeutic agents.

應用

Melphalan has been used as a drug along with HDAC-inhibitor JNJ-26481585 to treat multiple myeloma (MM) in cell lines and as a chemotherapeutic agent for breast cancer cell line.

生化／生理作用

In rat, melphalan in isolated lung perfusion (ILP) functions as a potent therapeutics for sarcomatous pulmonary metastases. It forms DNA intrastrand crosslinks by bifunctional alkylation in 5′-GGC sequences. Melphalan acts as a bone-marrow depressant and is implicated in the treatment of multiple myeloma and ovarian cancer.

Melphalan is an antineoplastic agent.

安全資訊

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H300,H317,H340,H350,H361
• 防範說明: P201 - P280 - P301 + P310 + P330 - P302 + P352
• 危險分類: Acute Tox. 2 Oral - Carc. 1A - Muta. 1B - Repr. 2 - Skin Sens. 1
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges