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Key Documents

L3023

Sigma-Aldrich

脂多糖 来源于大肠杆菌 0111:B4

Detoxified

同義詞:

LPS

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About This Item

EC號碼:
MDL號碼:
分類程式碼代碼:
12352201
NACRES:
NA.25

生物源

Escherichia coli (O111:B4)

品質等級

形狀

lyophilized powder

顏色

white to beige

溶解度

water: soluble

運輸包裝

ambient

儲存溫度

2-8°C

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一般說明

本品从 O111:B4 血清型大肠杆菌中提取,经色谱法纯化。来源菌株来自私人收藏。脂质 A 部分已通过碱水解部分脱脂。去除类脂 A 的脂肪酸部分可产生一种去毒 LPS,其内毒素级别比母体 LPS 低 10,000 倍。

應用

脂多糖(LPS)是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式(PAMP)的Toll样受体蛋白家族成员Toll样受体4(TLR4)刺激先天性免疫系统细胞。

生化/生理作用

脂多糖(LPS)位于膜的外层,并且在非包封的菌株中,其暴露于细胞表面。它们有助于外膜的完整性,并可保护细胞免受胆汁盐和亲脂性抗生素的作用。

準備報告

色谱纯化;碱水解脱脂
该产品可溶于水(5mg / ml)或细胞培养基(1mg / ml),产生浑浊的淡黄色溶液。当涡旋并升温至70-80 oC后,在盐水中可获得更高浓度的溶液(20mg/ml),但仍然是浑浊的溶液。脂多糖是一种在各种溶剂中都形成胶束的分子。在水和磷酸盐缓冲盐水中可观察到浑浊的溶液。有机溶剂无法使溶液变澄清。甲醇会产生含有漂浮物的混浊悬浮液,而水会产生均匀的混浊溶液。

其他說明

为了全面了解我们针对客户研究提供的各种脂多糖产品,建议您访问我们的碳水化合物分类页面。

象形圖

Skull and crossbones

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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存取文件庫

Hua Qiu et al.
Drug design, development and therapy, 13, 589-600 (2019-02-28)
Jie-Du-Hua-Yu (JDHY) granule is a combination of six traditional Chinese medicines with known therapeutic effect in treating acute liver failure (ALF). The aim of this study was to investigate the amelioration efficacy of JDHY in lipopolysaccharide/D-galactosamine (LPS/D-GalN)-induced ALF in rat
Carol L Ladner-Keay et al.
Prion, 10(6), 466-483 (2016-12-03)
Conversion of native cellular prion protein (PrPc) from an α-helical structure to a toxic and infectious β-sheet structure (PrPSc) is a critical step in the development of prion disease. There are some indications that the formation of PrPSc is preceded
Gabrielle R Andrade et al.
Human vaccines & immunotherapeutics, 10(10), 2864-2874 (2014-12-09)
E. coli O111 strains are responsible for outbreaks of blood diarrhea and hemolytic uremic syndrome throughout the world. Because of their phenotypic variability, the development of a vaccine against these strains which targets an antigen that is common to all
Rhonda H Wilson et al.
American journal of respiratory and critical care medicine, 180(8), 720-730 (2009-08-08)
In humans, immune responses to inhaled aeroallergens develop in the lung and draining lymph nodes. Many animal models of asthma bypass this route and instead use intraperitoneal injections of allergen using aluminum hydroxide as an adjuvant. We investigated whether allergic
Mohamed El Gazzar et al.
Molecular and cellular biology, 29(7), 1959-1971 (2009-01-23)
Epigenetic silencing of tumor necrosis factor alpha (TNF-alpha) and interleukin 1beta (IL-1beta) transcription occurs in blood leukocytes of animals and humans after the initiation of severe systemic inflammation (SSI). We previously reported that the epigenetic signature requires induction of NF-kappaB

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