K4389

KR-32568

≥98% (HPLC), solid

• 同義詞: [5-(2-Methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine
• 經驗公式（希爾表示法）: C₁₃H₁₂FN₃O₂
• CAS號碼: 852146-73-7
• 分子量：: 261.25
• MDL號碼: MFCD08705324
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724522
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 顏色: white
• 溶解度: DMSO: ~10 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: Cc1ccc(F)cc1-c2ccc(o2)C(=O)NC(N)=N
• InChI: 1S/C13H12FN3O2/c1-7-2-3-8(14)6-9(7)10-4-5-11(19-10)12(18)17-13(15)16/h2-6H,1H3,(H4,15,16,17,18)
• InChI 密鑰: DTLDHYBZLVASJQ-UHFFFAOYSA-N
• 基因資訊: human ... SLC9A1(6548)

描述

生化／生理作用

Sodium/hydrogen exchanger-1 (NHE-1) inhibitor; IC₅₀ = 0.23 μM; inhibited NHE-1-mediated rabbit platelet swelling; in anesthetized rats, reduced infarct size from 67% (control) to 43% (at 0.1 mg/kg) and 24% (at 1.0 mg/kg); reduced number of ventricular premature beats from 530 to 266 (at 0.1 mg/kg) and 115 (at 1.0 mg/kg); reduced ventricular fibrillation incidence from 17 to 8 (0.1 mg/kg) and 0 (1.0 mg/kg); implications for research and treatment of myocardial ischemic diseases.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H315,H319,H335
• 防範說明: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter