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I4632

Sigma-Aldrich

2-亚氨基生物素

≥98% (TLC)

同義詞:

六氢-2-亚氨基-1H-噻吩 [3,4-d] 咪唑-4-戊酸, 胍基生物素

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About This Item

經驗公式(希爾表示法):
C10H17N3O2S
CAS號碼:
分子量::
243.33
Beilstein:
18952
MDL號碼:
分類程式碼代碼:
12352203
PubChem物質ID:
NACRES:
NA.46

生物源

synthetic (organic)

化驗

≥98% (TLC)

形狀

powder

溶解度

1 M HCl: 50 mg/mL, clear, colorless

儲存溫度

2-8°C

SMILES 字串

[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=N)N2

InChI

1S/C10H17N3O2S/c11-10-12-6-5-16-7(9(6)13-10)3-1-2-4-8(14)15/h6-7,9H,1-5H2,(H,14,15)(H3,11,12,13)/t6-,7-,9-/m0/s1

InChI 密鑰

WWVANQJRLPIHNS-ZKWXMUAHSA-N

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一般說明

2-亚氨基生物素是生物素的环状胍基类似物,在高 pH (> 9) 下对亲和素具有高亲和力,在低 pH (< 6) 下具有低亲和力。亚氨基生物素化的蛋白质选择性地包含在 pH 9-11 的亲和素柱内,可在 pH 4 洗脱或加入生物素洗脱。该技术可用于研究细胞表面蛋白,通过标记和选择性地从完整的人红细胞表面回收高碘酸盐敏感的成分。2-亚氨基生物素通过其胍基可逆性抑制 NOS(一氧化氮合酶)。它抑制 NO 的生物合成,了解这类重要酶的结合位点相互作用可能很重要。NOS 氧化 L-精氨酸的胍基氮生成一氧化氮和 L-瓜氨酸。

應用

已将 2-亚氨基生物素用作竞争性抑制剂,与链霉亲和素的生物结合位点结合,以恢复荧光信号。

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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