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Merck
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重要文件

I3400

Sigma-Aldrich

Interferon-γ-Inducible Protein-10 human

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

同義詞:

CXCL10, IP-10

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About This Item

MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.32

生物源

human

品質等級

重組細胞

expressed in E. coli

化驗

≥97% (SDS-PAGE)

形狀

lyophilized powder

效力

0.015-0.075 μg/mL ED50 (chemoattract mouse BaF3 cells transfected with hCXCR3)
0.03-0.18 μg/mL ED50 (chemoattract T-Lymphocytes)

分子量

8.7 kDa

包裝

pkg of 10 μg

雜質

endotoxin, tested

UniProt登錄號

儲存溫度

−20°C

基因資訊

human ... CXCL10(3627)

一般說明

The gene for C-X-C motif chemokine ligand 10 (CXCL10), also known as interferon-γ-inducible protein-10 (IP-10), is mapped to human chromosome 4q21.1. IP-10 is secreted by monocytes, neutrophils, endothelial cells, keratinocytes, fibroblasts, mesenchymal cells, dendritic cells, astrocytes and hepatocytes. It is a polypeptide of 78 amino acids. Human IP-10 shows 67% amino acid homology to mouse CRG-2.

生化/生理作用

IP-10 (interferon-γ-inducible protein-10) protein is a proinflammatory chemokine which controls immune responses. It interacts with chemokine receptor 3 (CXCR3) and activates leukocytes including T cells, eosinophils, monocytes and natural killer cells. Mutations in IP-10 are associated with rheumatoid arthritis. In humans with chronic hepatitis C virus (HCV) infection or HCV/human immunodeficiency virus (HIV) co-infection, IP-10 is linked with obesity and insulin resistance.
IP-10, a chemoattractant for activated T lymphocytes, is a potent inhibitor of angiogenesis and displays thymus-dependent anti-tumor effects.

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose containing 50 μg bovine serum albumin per 1 μg of cytokine.

分析報告

The biological activity is measured by its ability to chemoattract mouse BaF/3 cells transfected with hCXCR3.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Daniel Kotrych et al.
Rheumatology international, 35(8), 1319-1323 (2015-02-24)
Chemokines (CXCL) and their receptors play important roles in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to examine the associations between polymorphisms in the CXCL9 (rs3733236 G>A) and CXCL10 (rs8878 A>G) genes and RA. We
Chia-Chu Chang et al.
Scientific reports, 5, 10096-10096 (2015-05-12)
Nonalcoholic fatty liver disease (NAFLD) is an important risk factor for the development of type 2 diabetes mellitus. Interferon gamma-induced protein 10 (IP-10), a proinflammatory chemokine, plays a crucial role in inflammatory diseases. This cross-sectional pilot study investigated whether circulating

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