跳轉至內容
Merck
全部照片(1)

重要文件

查看所有文件

I2406

Sigma-Aldrich

IL-11 human

>97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

同義詞:

IL-11

登入查看組織和合約定價
全部照片(1)

About This Item

MDL號碼:
MFCD00212208
分類程式碼代碼:
12352202
NACRES:
NA.32

product name

Interleukin-11 human, >97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

生物源

human

品質等級

100

重組細胞

expressed in baculovirus infected Sf21 cells

化驗

>97% (SDS-PAGE)

形狀

lyophilized powder

效力

0.06-0.24 ng/mL ED50

分子量

23 kDa

包裝

pkg of 5 μg

技術

cell culture | mammalian: suitable

雜質

endotoxin, tested

UniProt登錄號

P20809

儲存溫度

−20°C

基因資訊

human ... IL11(3589)

尋找類似的產品？ 前往 產品比較指南

相關類別

一般說明

Interleukin-11 (IL-11) is synthesized by many mesenchymal origin cells like keratinocytes, synoviocytes, fibroblasts, bone marrow stromal cells, osteoblasts, and chondrocytes.
The gene IL-11 (interleukin 11) is mapped to human chromosome 19q13.4. It is a secreted protein.

生化／生理作用

Interleukin 11 (IL-11) is involved in promoting tissue fibrosis and regulates the function of chondrocytes, synoviocytes, and B cells. It is also involved in bone metabolism and tissue remodeling.
Interleukin-11, also called adipogenesis inhibitory factor (AGIF), is a pleotropic cytokine that acts on hematopoietic progenitor cells and stromal cells. Although recombinant human IL-11 has a predicted molecular mass of 19 kDa, it migrates as a 23 kDa band in SDS-PAGE. It is a functional homolog of IL-6, inducing the proliferation of certain plasmacytoma cell lines and acute phase protein secretion in the liver. IL-11 stimulates the production of erythrocytes, megakaryocytes, and T cell development of antibody producing B cells.

外觀

Lyophilized from a 0.2 μm filtered solution of PBS and EDTA with BSA as a carrier protein.

分析報告

The biological activity is measured in a cell proliferation assay using T11, a subline of the IL-6-dependent murine plasmacytoma cell line T1165.85.2.1 that has been adapted to grow in IL-11.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

V F Quesniaux et al.
Blood, 80(5), 1218-1223 (1992-09-01)
Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a primate bone marrow stromal cell line, has been shown to stimulate T-cell-dependent B-cell maturation, megakaryopoiesis, and various stages of myeloid differentiation, but to inhibit adipogenesis. Because stromal cells are essential for
I Kawashima et al.
FEBS letters, 283(2), 199-202 (1991-06-03)
A cDNA encoding a novel adipogenesis inhibitory factor (AGIF) that inhibits the process of adipogenesis in mouse 3T3-L1 preadipocytes was cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102. The cloned cDNA contains an open
W Klein et al.
Genes and immunity, 3(8), 494-496 (2002-12-18)
Inflammatory bowel diseases (IBD) are multifactorial disorders characterised by the host's inability to limit the inflammatory response to luminal antigens. The association of polymorphisms in the CARD15 gene with Crohn's disease (CD) demonstrates the relevance of activated transcription factor NF(kappa)B
I Kawashima et al.
Progress in growth factor research, 4(3), 191-206 (1992-01-01)
Interleukin-11 (IL-11) is a novel stroma-derived cytokine that acts on both hematopoietic progenitors and stromal cells. IL-11 was originally identified in a medium conditioned by the macaque bone marrow-derived stromal cell line PU-34 and cloned as a growth factor for
Interleukin-11: a cytokine signaling through gp130 with pleiotropic effects and potential clinical utility within and outside the hematopoietic system.
Jacobsen, S.E.W. et al.
The Cytokine Handbook, 365-365 (1998)
查看所有相關論文

文章

Interleukin Family (IL)

The Interleukins comprise a disparate group of cytokines and growth factors that are produced by and released from leukocytes. Interleukin-1β (1L-1β) is released primarily from stimulated macrophages and monocytes and plays a key role in inflammatory and immune responses and may induce anti-tumor immunity.

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務