H7291

白细胞介素4 人

IL-4, potency:, recombinant, expressed in HEK 293 cells, HumanKine^®, suitable for cell culture

• MDL號碼: MFCD00151705
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 生物源: human
• 品質等級: 100
• 重組細胞: expressed in HEK 293 cells
• 化驗: >95% (SDS-PAGE)
• 形狀: lyophilized powder
• 效力: ≤0.6 ng/mL EC₅₀
• 品質: endotoxin tested
• 分子量: dimer 14-19 kDa (glycosylated)
• 包裝: pkg of 1 mg; pkg of 10 μg; pkg of 100 μg
• 製造商／商標名: HumanZyme
• 技術: cell culture | mammalian: suitable
• 雜質: <1 EU/μg
• UniProt登錄號: P05112
• 儲存溫度: −20°C
• 基因資訊: human ... IL4(3565)

描述

一般說明

Interleukin-4 (IL-4) is a pleiotropic cytokine and a complex glycoprotein mapped to human chromosome 5q31.1. It is produced by mast cells, basophils and a subset of activated T cells.

生化／生理作用

Interleukin-4 (IL-4) interacts with interleukin 13 and is an interleukin-4 receptor ligand. It regulates IgE and IgG1 production by B cells. IL-4 favors glial and neuronal differentiation and regulates differentiation of naive cluster of differentiation CD4⁺ T cells to the T helper type 2 (TH2) cells. Polymorphism in the IL-4 gene is implicated in immune and inflammatory disorders. In cerebral infarction, IL-4 levels are elevated.

外觀

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

準備報告

HumanKine Interleukin-4 (IL-4), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 14-19 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

分析報告

The activity is determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

法律資訊

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable