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Key Documents

I1896

Sigma-Aldrich

白介素-13 来源于小鼠

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

同義詞:

IL-13

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About This Item

MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

mouse

品質等級

重組細胞

expressed in E. coli

化驗

≥97% (SDS-PAGE)

形狀

lyophilized powder

效力

1-10 ng/mL EC50

分子量

11.5 kDa (predicted; 9 kDa under reducing conditions)

包裝

pkg of 5 μg

技術

cell culture | mammalian: suitable

雜質

endotoxin, tested

UniProt登錄號

儲存溫度

−20°C

基因資訊

mouse ... Il13(16163)

生化/生理作用

白细胞介素-13是由小鼠和人类中活化的Th2细胞产生的多效性细胞因子。IL-13主要分泌为132个氨基酸的未糖基化蛋白,分子量为10,000道尔顿。对小鼠IL-13基因的4.3 kb DNA片段进行测序,并以映射11号染色体的单拷贝形式出现。在人类中,IL-13基因的4.6 kb DNA片段以单拷贝形式出现,并映射到5号染色体。IL-13诱导B细胞增殖,还诱导IgE转换。使用人红白血病细胞系TF-1在培养物中检测人和小鼠IL-13产品的增殖活性。

外觀

从含有50 μg牛血清白蛋白(BSA)/1 μg细胞因子的磷酸盐缓冲盐水(PBS)(pH值7.4)的0.2 μm过滤溶液中冻干

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Luke Hatchwell et al.
Thorax, 70(9), 854-861 (2015-06-26)
Asthma exacerbations represent a significant disease burden and are commonly caused by rhinovirus (RV), which is sensed by Toll-like receptors (TLR) such as TLR7. Some asthmatics have impaired interferon (IFN) responses to RV, but the underlying mechanisms of this clinically
Kihyuk Shin et al.
Clinical and experimental medicine, 15(3), 233-244 (2014-06-14)
The leukotrienes (LTs) enhance allergen- and interleukin (IL)-13-dependent allergic lung inflammatory disease. However, the precise requirement of LTs and the mechanism by which they elicit allergic lung responses remain uncertain. To clarify the involvement of LTs in respiratory allergen- and
Gui Yang et al.
The Journal of biological chemistry, 290(20), 12858-12867 (2015-04-04)
Restoration of the antigen (Ag)-specific immune tolerance in an allergic environment is refractory. B cells are involved in immune regulation. Whether B cells facilitate the generation of Ag-specific immune tolerance in an allergic environment requires further investigation. This paper aims
C Abrial et al.
British journal of pharmacology, 172(17), 4319-4330 (2015-06-05)
15-Lipoxygenase (15-LOX) activity is associated with inflammation and immune regulation. The objectives of the present study were to investigate the expression of 15-LOX-1 and 15-LOX-2 and evaluate the enzymes' roles in the polarization of human lung macrophages (LMs) in response
Haixia Zhao et al.
Toxicology and applied pharmacology, 279(3), 311-321 (2014-07-16)
M2 macrophage polarization is implicated in colorectal cancer development. Isoliquiritigenin (ISL), a flavonoid from licorice, has been reported to prevent azoxymethane (AOM) induced colon carcinogenesis in animal models. Here, in a mouse model of colitis-associated tumorigenesis induced by AOM/dextran sodium

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