推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
產品線
Prestige Antibodies® Powered by Atlas Antibodies
形狀
buffered aqueous glycerol solution
物種活性
human
技術
immunoblotting: 0.04-0.4 μg/mL
immunohistochemistry: 1:50-1:200
免疫原序列
GSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... FZD8(8325)
一般說明
Frizzled class receptor 8 (FZD8) belongs to the frizzled family of receptors and encodes a wingless/integrase-1 (WNT) receptor. It consists of frizzled like cysteine-rich domain, seven transmembrane domains, and a C-terminal Ser/Thr-X-Val motif. The protein is expressed in brain, kidney, heart, pancreas and skeletal muscle. The gene is located on human chromosome 10p11.21. It is a cancer associated gene.
免疫原
frizzled class receptor 8
應用
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.
Anti-FZD8 antibody produced in rabbit has been used in immunohistochemistry and western blotting.
生化／生理作用
Frizzled class receptor 8 (FZD8) plays an important role in airway inflammation linked to chronic bronchitis. Downregulation of this protein is related to microRNA-520b (miR-520b) inhibited cell proliferation, migration, and invasion of spinal osteosarcoma cells. It functions as a potential therapeutic target for prostate cancer bone metastasis. The protein activates β-catenin-TCF pathway and is important in several tumors.
特點和優勢
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
聯結
Corresponding Antigen APREST83761
外觀
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
法律資訊
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Jennifer A Bohn et al.
Nucleic acids research, 46(1), 362-386 (2017-11-23)
Human Pumilio proteins, PUM1 and PUM2, are sequence specific RNA-binding proteins that regulate protein expression. We used RNA-seq, rigorous statistical testing and an experimentally derived fold change cut-off to identify nearly 1000 target RNAs-including mRNAs and non-coding RNAs-that are functionally
Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2
Saitoh T, et al.
International Journal of Oncology, 18(5), 991-996 (2001)
Microrna-520b suppresses proliferation, migration, and invasion of spinal osteosarcoma cells via downregulation of frizzled-8
Wang J, et al.
Oncology Research, 25(8), 1297-1304 (2017)
FZD8, a target of p53, promotes bone metastasis in prostate cancer by activating canonical Wnt/beta-catenin signaling
Liet Q, et al.
Cancer Letters, 402(8), 166-176 (2017)
Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma
Yang Q, et al.
Oncotarget, 8(45), 78989-78989 (2017)
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