H5527

潮霉素 B 溶液 来源于吸水链霉菌

≥60% (HPLC), 45-60 mg/mL in H₂O, γ-irradiated

• 同義詞: Hygromycin b, Hygrovetine
• 經驗公式（希爾表示法）: C₂₀H₃₇N₃O₁₃
• CAS號碼: 31282-04-9
• 分子量：: 527.52
• Beilstein: 6755837
• MDL號碼: MFCD06795479
• 分類程式碼代碼: 51102829
• PubChem物質ID: 24895698
• NACRES: NA.85

屬性

• 生物源: Streptomyces hygroscopicus
• 品質等級: 200
• 無菌: γ-irradiated
• 濃度: ≥60% (HPLC); 45-60 mg/mL in H₂O
• 顏色: yellow-brown to orange
• 抗生素活性譜: viruses
• 作用方式: protein synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O
• InChI: 1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1
• InChI 密鑰: GRRNUXAQVGOGFE-XKIAHZFYSA-N

描述

一般說明

Chemical structure: aminoglycoside

應用

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.

生化／生理作用

抗菌剂和抗真菌剂。作用方式：在原核生物和真核生物中，通过诱导 mRNA 模板的误读而抑制蛋白质合成。它可选择性透入因病毒感染而变得可渗透的细胞。

注意

Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.

準備報告

This product is a solution that is =60% (HPAE), 45-60 mg/mL in H₂O, and γ-irradiated .

安全資訊

• 象形圖: GHS06,GHS08,GHS05
• 訊號詞: Danger
• 危險聲明: H301 + H311,H318,H330,H334
• 防範說明: P260 - P280 - P284 - P301 + P310 - P305 + P351 + P338 - P310
• 危險分類: Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Eye Dam. 1 - Resp. Sens. 1
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter