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Key Documents

H2775

Sigma-Aldrich

DL - 苏式 -β-羟基天冬氨酸

同義詞:

苏式 -2-氨基-3-羟基琥珀酸

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About This Item

經驗公式(希爾表示法):
C4H7NO5
CAS號碼:
分子量::
149.10
EC號碼:
MDL號碼:
分類程式碼代碼:
12352106
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.32

品質等級

儲存溫度

−20°C

SMILES 字串

N[C@H]([C@@H](O)C(O)=O)C(O)=O

InChI

1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m1/s1

InChI 密鑰

YYLQUHNPNCGKJQ-JCYAYHJZSA-N

基因資訊

human ... GLUL(2752)
mouse ... GLUL(14645)

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一般說明

DL -苏式-β-羟基天冬氨酸 (THA) 是一种谷氨酸摄取抑制剂。

應用

DL-苏氨酸-β-在插管 sprague dawley 大鼠中使用羟基天冬氨酸 (THA) 阻断谷氨酸盐转运。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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Nina Bionda et al.
Amino acids, 42(1), 285-293 (2010-11-18)
A simple and practical general synthetic protocol towards orthogonally protected tHyAsp derivatives fully compatible with Fmoc solid-phase peptide synthetic methodology is reported. Our approach includes enantioresolution of commercially available D: ,L: -tHyAsp racemic mixture by co-crystallization with L: -Lys, followed
Ewa Nagańska et al.
Folia neuropathologica, 48(1), 35-44 (2010-04-13)
Erythropoietin (EPO) is a chemokine hormone that is widely distributed throughout the body including nervous system. For last years its role as cytokine involved in many physiological processes out of the bone marrow has been suggested. Moreover, it plays a
Claudio Laurido et al.
TheScientificWorldJournal, 2012, 279147-279147 (2012-04-27)
N-methyl-D-aspartic acid receptor (NMDAr) activation requires the presence of D-serine, synthesized from L-serine by a pyridoxal 5'-phosphate-dependent serine racemase (SR). D-serine levels can be lowered by inhibiting the racemization of L-serine. L-serine-O-sulfate (LSOS) and L-erythro-3-hydroxyaspartate (LEHA), among others, have proven
A Hirata et al.
Brain research, 771(1), 37-44 (1998-02-12)
Excitotoxicity secondary to the loss of glutamate transporters (GluT) has been proposed as a possible pathogenetic mechanism for neuronal degeneration in amyotrophic lateral sclerosis. We therefore investigated whether prolonged in vivo pharmacologic inhibition of GluT would result in neuronal damage
A Klegeris et al.
Journal of neuroimmunology, 78(1-2), 152-161 (1997-10-23)
Glutamate, an excitatory neurotransmitter, is neurotoxic at high concentrations. Neuroglial cells, including astrocytes and microglia, play an important role in regulating its extracellular levels. Cultured human monocytic THP-1 cells increased their glutamate secretion following 18 and 68 h exposure to

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