H0786

Heregulin-β, EGF Domain human

≥80% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution

• 同義詞: HRG-β
• MDL號碼: MFCD01867052
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 生物源: human
• 品質等級: 200
• 重組細胞: expressed in E. coli
• 化驗: ≥80% (SDS-PAGE)
• 形狀: buffered aqueous glycerol solution
• 分子量: 185 kDa
• 包裝: pkg of 100 μg
• 儲存條件: avoid repeated freeze/thaw cycles
• UniProt登錄號: Q02297
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 基因資訊: human ... NRG1(3084)

描述

一般說明

Truncated human sequence (amino acids 178-241) corresponding to the EGF domain and purified as a GST-fusion protein, cleaved with thrombin.

生化／生理作用

Growth factor ligand for ErbB3 and ErbB4 receptor tyrosine kinases. The binding of HRG results in receptor dimerization and receptor trans-autophosphorylation. The phosphorylated receptors recruit cellular signaling proteins, initiating signaling pathways.

外觀

Solution in phosphate buffered saline containing 30% glycerol.

分析報告

Stimulates tyrosine phosphorylation of the ErbB-3/HER-3 receptor.

The biological activity is measured by its ability to activate the c-ErbB3/HER-3 receptor in treated MCF-7 cells.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable