生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
VA-11.25, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~34 kDa
物種活性
mouse, rat, human
濃度
~1.0 mg/mL
技術
immunocytochemistry: suitable
indirect ELISA: suitable
western blot: 1-2 μg/mL using rat galectin 8 recombinant protein
同型
IgM
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... LGALS8(3964)
mouse ... Lgals8(56048)
rat ... Lgals8(116641)
一般說明
半乳凝素特异性结合β-半乳糖苷。目前已发现15种哺乳动物半乳凝素。半乳凝素8含有两个由短肽连接的CRD结构。
抗-半乳凝素8（小鼠IgM亚型）单克隆抗体来自于小鼠骨髓瘤细胞和重组大鼠半乳凝素8免疫的BALB/c小鼠脾细胞融合而VA-11.25杂交瘤细胞。半乳凝素属于糖类结合蛋白家族。就这一家族的蛋白而言，半乳凝素8的独特性在于通过同一基因编码出多种形式的蛋白。
特異性
本抗体与半乳凝素3和半乳凝素9的交叉反应性较低。
免疫原
重组大鼠半乳凝素8。
應用
小鼠抗半乳凝素-8抗体已用于：
- 免疫印迹
- 免疫细胞化学
- 酶联免疫吸附测定(ELISA)
生化／生理作用
半乳凝素(Galectin)属糖结合蛋白家族。这类蛋白在富含N-乙酰乳糖胺复合糖的糖识别域(CRD)和特异性上具有相似性。半乳凝素与糖类的结合可调控细胞增殖、死亡和迁移，参与癌症发生发展。半乳凝素8是一种分泌型蛋白质，两个CRD结构域需要同时激活才能调节细胞黏附。它可与整合素形成复合物，启动整合素介导的信号级联放大。与之相反的是，过量蛋白会通过与整合素相互作用而负性调节细胞黏附。这些半乳凝素8相关信号有助于确定可进行细胞黏附和迁移的区域。它可能参与肿瘤转化。
外觀
溶于0.01 M磷酸盐缓冲液（pH 7.4）中，含有15 mM叠氮化钠。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Human galectin-8 isoforms and cancer
Bidon WN and Le Pennec JP
Glycoconjugate Journal, 19(7-9), 557-563 (2002)
Laurent Ingrassia et al.
Current medicinal chemistry, 13(29), 3513-3527 (2006-12-16)
Galectins form a family of carbohydrate-binding proteins defined by their affinity for beta-galactosides containing glycoconjugates. The carbohydrate recognition domain (CRD) is responsible for the specificity of galectins for saccharides. This binding may result in modulated cell proliferation, cell death and
G A Rabinovich
Cell death and differentiation, 6(8), 711-721 (1999-09-01)
Galectins constitute a family of evolutionarily conserved animal lectins, which are defined by their affinity for poly-N-acetyllactosamine-enriched glycoconjugates and sequence similarities in the carbohydrate recognition domain. During the past decade, attempts to dissect the functional role for galectins in vivo
Nathalie Bidon-Wagner et al.
Glycoconjugate journal, 19(7-9), 557-563 (2004-02-06)
Galectins are animal lectins that can specifically bind beta-galactosides. Thirteen galectins have already been described. This review focuses on a specific member of this family: galectin-8. This galectin was discovered in prostate cancer cells eight years ago and has been
Yehiel Zick et al.
Glycoconjugate journal, 19(7-9), 517-526 (2004-02-06)
Galectin-8 belongs to the family of tandem-repeat type galectins. It consists as several isoforms, each made of two domains of approximately 140 amino-acids, both having a carbohydrate recognition domain (CRD). These domains are joined by a 'link peptide' of variable
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