全部照片(3)
About This Item
經驗公式（希爾表示法）:
C6H9NO2 · HCl
CAS號碼:
分子量：:
163.60
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推薦產品
形狀
solid
品質等級
顏色
white
溶解度
H2O: soluble (refrigerate if not used immediately.)
methanol: slightly soluble
neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily)
SMILES 字串
Cl[H].OC(=O)C1=CCNCC1
InChI
1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H
InChI 密鑰
SUWREQRNTXCCBL-UHFFFAOYSA-N
基因資訊
human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562)
應用
Isoguvacine hydrochloride has been used as a γ-aminobutyric acid type A (GABAA) receptor agonist:
- to study its effects on neuronal activity in rats
- to study its antiallodynic effect in rats
- to study its effects on baroreflex gains in rats
生化／生理作用
Isoguvacine is a strong γ-aminobutyric acid A (GABAA) receptor agonist.
特點和優勢
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
客戶也查看了
Roman Tyzio et al.
Epilepsia, 48 Suppl 5, 96-105 (2007-10-04)
The timing of the developmental switch in the GABA(A) mediated responses from excitatory to inhibitory was studied in Wistar rat CA3 hippocampal pyramidal cells using gramicidin perforated patch-clamp and extracellular recordings. Gramicidin perforated patch recordings revealed a gradual developmental shift
Ke-Zhong Shen et al.
The Journal of physiology, 573(Pt 3), 697-709 (2006-04-15)
The subthalamic nucleus (STN) plays an important role in movement control by exerting its excitatory influence on the substantia nigra pars reticulata (SNR), a major output structure of the basal ganglia. Moreover, excessive burst firing of SNR neurons seen in
Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds.
P Krogsgaard-Larsen et al.
Journal of neurochemistry, 30(6), 1377-1382 (1978-06-01)
Tero Viitanen et al.
The Journal of physiology, 588(Pt 9), 1527-1540 (2010-03-10)
GABAergic excitatory [K(+)](o) transients can be readily evoked in the mature rat hippocampus by intense activation of GABA(A) receptors (GABA(A)Rs). Here we show that these [K(+)](o) responses induced by high-frequency stimulation or GABA(A) agonist application are generated by the neuronal
N G Bowery et al.
Experientia, 34(9), 1193-1195 (1978-09-15)
The GABA-mimetic activities of 4 analogues muscimol, isonipecotic acid, isoguvacine and N-methyl isoguvacine have been examined at the GABA receptor in the rat isolated superior cervical ganglion. The depolarizing action of all 4 analogues could be selectively antagonized by bicuculline
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務