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Merck
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重要文件

F5386

Sigma-Aldrich

纤维蛋白 来源于人类血浆

insoluble powder

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About This Item

CAS號碼:
9001-31-4
EC號碼:
232-597-0
MDL號碼:
MFCD00131058
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

human plasma

品質等級

200

形狀

powder

技術

indirect ELISA: suitable

UniProt登錄號

P02671
P02675
P02679

SMILES 字串

N(CC(=O)NC)C(=O)CN

InChI

1S/C5H11N3O2/c1-7-5(10)3-8-4(9)2-6/h2-3,6H2,1H3,(H,7,10)(H,8,9)

InChI 密鑰

BWGVNKXGVNDBDI-UHFFFAOYSA-N

基因資訊

human ... FGA(2243) , FGB(2244) , FGG(2266)

一般說明

纤维蛋白通过纤维蛋白原的凝血酶交联产生。纤维蛋白原由两个单体组成，每个单体含有三条多肽链。纤维蛋白原是一种主要的血浆蛋白。

應用

来自人血浆中的纤维蛋白已用于：
  • 纤维蛋白原和纤维蛋白的体外切割
  • 作为拉曼光谱真成分分析（TCA）和主成分分析（PCA）的参考
  • 作为拉曼光谱的参考，以研究不同多金属氧酸盐（POM）的结合机理和结合效率。

生化／生理作用

纤维蛋白是初级凝血过程中的重要生物聚合物。它为组织修复过程中浸润细胞提供了支架。纤维蛋白被广泛用作组织再生应用的组织密封剂，因为它能够形成生物相容性的物理结构。它也被用于细胞和生物活性分子的输送系统。纤维蛋白基质类似于天然胰腺，可作为胰岛移植的支架材料。纤维蛋白已在研究中用于获得纤维蛋白特异性单克隆抗体（mAb）。这些mAb可用于确定它们在纤维蛋白聚合中的作用以及在血浆中纤维蛋白定量中的用途。

準備報告

通过凝固纤维蛋白原制备以产生交联纤维蛋白

免責聲明

供研究使用在法国，在用于科研目的时（包括进口和出口活动（《公共健康法》第L 1211-1条，第2节））该产品为管制品。购买者（即最终用户）需要获得《公共健康法》法第L 1211-1条规定的法国研究部的进口授权。订购本产品即表明您确认已经获得合适的进口授权。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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分析證明 (COA)

Lot/Batch Number
SLCF5510
095F9462V
085F9457
056F9467
095F9462

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Weimin Wu et al.
The Journal of investigative dermatology, 134(1), 256-263 (2013-07-24)
Dermatopontin (DP) is a small extracellular matrix component in the dermis. Fibrin is a major component of a provisional matrix that is formed just after wounding. Previously, we found that DP was present in the provisional matrix, and it interacted
Abraham R Alfonso et al.
Acta biomaterialia, 9(9), 8149-8157 (2013-06-26)
Tissue engineered heart valves (TEHVs) may provide a permanent solution to congenital heart valve disease by permitting somatic valve growth in the pediatric patient. However, to date, TEHV studies have focused primarily on collagen, the dominant component of valve extracellular
James C Fredenburgh et al.
The Journal of biological chemistry, 288(41), 29394-29402 (2013-08-31)
The nonspecific binding of heparin to plasma proteins compromises its anticoagulant activity by reducing the amount of heparin available to bind antithrombin. In addition, interaction of heparin with fibrin promotes formation of a ternary heparin-thrombin-fibrin complex that protects fibrin-bound thrombin
Kristen T Morin et al.
Experimental cell research, 319(16), 2409-2417 (2013-06-27)
In vitro models of endothelial assembly into microvessels are useful for the study of angiogenesis and vasculogenesis. In addition, such models may be used to provide the microvasculature required to sustain engineered tissues. A large range of in vitro models
Matteo Centola et al.
Tissue engineering. Part A, 19(17-18), 1960-1971 (2013-04-25)
Standard cartilage tissue engineering approaches, for example, matrix-induced autologous chondrocyte implantation (MACI), consist of the implantation of cell-based constructs whose survival and further development first depend on the degree of graft maturity at the time of surgery (e.g., matrix production)
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