跳轉至內容
Merck
全部照片(1)

Key Documents

F0504

Sigma-Aldrich

Folate binding protein from bovine milk

lyophilized powder

登入查看組織和合約定價
全部照片(1)

About This Item

MDL號碼:
MFCD00131098
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

bovine milk

品質等級

200

形狀

lyophilized powder

用途

 mg sufficient for ~4,000 assays

成份

Protein, 20-40% modified Warburg-Christian

技術

ligand binding assay: suitable
surface plasmon resonance (SPR): suitable

容量

1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)

儲存溫度

−20°C

尋找類似的產品？ 前往 產品比較指南

應用

Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.

生化／生理作用

Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.

包裝

Package size based on protein content

品質

Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.

外觀

Lyophilized powder containing buffer salt as sodium citrate

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

客戶也查看了

Slide 1 of 1

1 of 1

叶酸 BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥97%

Sigma-Aldrich

F8758

叶酸

Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats
Jones ML, et al.
The Journal of Nutrition, 133(2), 489-495 (2003)
Radioisotopic assay for measurement of serum folate levels.
S Waxman et al.
Blood, 38(2), 219-228 (1971-08-01)
Radioassay of serum folate.
R T Dunn et al.
Clinical chemistry, 19(10), 1101-1105 (1973-10-01)
Martin D Forster et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 71(11), 945-950 (2007-08-23)
The alpha-folate receptor (alpha-FR) is a folate transporter with restricted expression levels in normal tissues. It is over-expressed in several cancers, particularly epithelial carcinomas, including nonmucinous ovarian carcinoma. It offers a novel therapeutic target for selective imaging and cytotoxic agents.
LRP2 mediates folate uptake in the developing neural tube
Kur E, et al.
Journal of Cell Science, jcs-140145 (2014)
查看所有相關論文

文章

Folic Acid Metabolism in Cancer

This issue of Biofiles reviews some of our newest and most innovative technologies and their specific applications toward cancer research. In preparing this issue of Biofiles, one is reminded how complex the disease of cancer is, and how difficult it is to identify one topic that is completely unrelated to any other.

Folic Acid Metabolism: A Role in Cancer's Cause and Cure

This article reviews some of our newest and most innovative technologies and their specific applications toward cancer research. It describes how complex the disease of cancer is, and how difficult it is to identify one topic that is completely unrelated to any other.

癌症中的叶酸代谢

本期生物档案回顾了我们的一些最新和最具创新性的技术及其在癌症研究中的具体应用。在准备本期生物档案时，有人指出癌症极为复杂，要确定一个与其他主题完全无关的主题极为困难。。

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務