推薦產品
重組細胞
expressed in Sf9 cells
品質等級
形狀
solution
比活性
≥2,000 unit/μg protein
分子量
126 kDa
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... PDE5A(8654)
一般說明
Research area: Cell SignallingPDE5is located in various tissues such as the kidney, brain, lungs, cardiac myocytes,vascular smooth muscle cells, penile corpus cavernosum, platelets, andgastrointestinal tissues.
生化／生理作用
PDE5调节血管平滑肌收缩，并参与血小板中的NO-cGMP信号传导以控制聚集。 PDE5也可能参与大脑中cGMP信号传导的调节，并可能调节压力诱导的心脏肥大和纤维化。
物理性質
N末端带有GST标签的126 kDa全长蛋白
單位定義
一个单位为在37℃和pH 7.4下每分钟将1.0皮摩尔的3′,5′-cGMP转化为5′-GMP。
外觀
以含40 mM Tris-HCl（pH 8.0）、110 mM NaCl、2.2 mM KCl、0.04%吐温®20和3 mM DTT的20%甘油溶液形式提供
法律資訊
TWEEN is a registered trademark of Croda International PLC
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Andrew T Bender et al.
Pharmacological reviews, 58(3), 488-520 (2006-09-14)
Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of the second messengers, cAMP and cGMP, by controlling their rates of degradation. There are 11 different PDE families, with each family typically having several different isoforms and splice
Felicia Akuamoa et al.
Toxicology in vitro : an international journal published in association with BIBRA, 73, 105130-105130 (2021-03-05)
Herbal supplements sold as 'all natural' on various markets in Accra (Ghana) and advertised as highly efficacious in treating erectile dysfunction (ED) were bought and analysed by a PDE-5 enzyme inhibition assay. The claimed efficacy of these products could be
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