E5411

恩镰孢菌素B

from Gnomonia errabunda, ≥95% (HPLC)

• 同義詞: N-Methylcyclo(L-Val-D-Hmb-N-methyl-L-Val-D-Hmb-N-methyl-L-Val-D-Hmb-);(3S,6R,9S,12R,15S,18R)-3,6,9,12,15,18-Hexaisopropyl-4,10,16-trimethyl-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
• 經驗公式（希爾表示法）: C₃₃H₅₇N₃O₉
• CAS號碼: 917-13-5
• 分子量：: 639.82
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 生物源: Gnomonia errabunda
• 品質等級: 200
• 化驗: ≥95% (HPLC)
• 溶解度: DMSO: 10 mg/mL; ethanol: 10 mg/mL; methanol: 10 mg/mL
• 儲存溫度: −20°C
• InChI: 1S/C33H57N3O9/c1-16(2)22-31(40)43-26(20(9)10)29(38)35(14)24(18(5)6)33(42)45-27(21(11)12)30(39)36(15)23(17(3)4)32(41)44-25(19(7)8)28(37)34(22)13/h16-27H,1-15H3/t22-,23-,24-,25+,26+,27+/m0/s1
• InChI 密鑰: MIZMDSVSLSIMSC-VYLWARHZSA-N

描述

生化／生理作用

Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42). Enniatins B and B1 inhibit the multi-drug resistance transporter Pdr5p from Saccharomyces cerevisiae, indicating their beneficial potential in cases of drug resistant patients.

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301 + H311 + H331
• 防範說明: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable