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E3520

Sigma-Aldrich

依布硒

powder, ≥98% (TLC)

同義詞:

2-苯基-1,2-苯并异硒唑-3 (2H)-酮

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About This Item

經驗公式（希爾表示法）:
C13H9NOSe
CAS號碼:
60940-34-3
分子量：:
274.18
MDL號碼:
MFCD00210937
分類程式碼代碼:
12352202
PubChem物質ID:
24278417
NACRES:
NA.77

product name

依布硒, cysteine modifier

品質等級

200

化驗

≥98% (TLC)

形狀

powder

mp

176-182  °C

溶解度

chloroform: 19.60-20.40 mg/mL, clear, yellow

儲存溫度

2-8°C

SMILES 字串

O=C1N([Se]c2ccccc12)c3ccccc3

InChI

1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H

InChI 密鑰

DYEFUKCXAQOFHX-UHFFFAOYSA-N

尋找類似的產品？ 前往 產品比較指南

一般說明

依布硒属于拟交感神经胺类物质。

應用

依布硒已用作：
  • 电压依赖性钙离子通道(VDCC)阻断剂
  • 谷胱甘肽过氧化物酶类似物，检测其对于小鼠

趾长伸肌（快肌）收缩诱导的脱氧葡萄糖(2-DG)摄取的影响
  • 葡萄糖脑苷脂酶抑制剂
  • 丙型肝炎病毒解旋酶抑制剂

生化／生理作用

一种具有抗氧化属性的有机硒化合物。在不存在巯基的情况下抑制哺乳动物脂氧合酶，并通过与半胱氨酸残基的相互作用抑制谷胱甘肽 S-转移酶和木瓜蛋白酶。还可通过共价修饰半胱氨酸残基抑制吲哚胺 2,3-双加氧酶，该作用可被二硫苏糖醇逆转。其还可抑制低密度脂蛋白 (LDL) 的氧化。
依布硒(Ebselen)是一种谷胱甘肽过氧化物酶类似物，具有抗炎活性。它还具有抗动脉粥样硬化效用。依布硒对多重耐药金黄色葡萄球菌(MRSA)感染具有抗菌性，可作为治疗MRSA引发的皮肤感染的潜力药物。它可作为神经保护剂，并在炎症相关的癌变中具有化学预防功效。

訊號詞

Danger

危險分類

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

儲存類別代碼

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

水污染物質分類（WGK）

WGK 3

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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存取文件庫

Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections
Thangamani S, et al.
Scientific reports, 5, 11596-11596 (2015)
Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening
Urban DJ, et al.
Combinatorial Chemistry & High Throughput Screening, 11(10), 817-824 (2008)
Diana Islam et al.
American journal of respiratory and critical care medicine, 199(10), 1214-1224 (2018-12-07)
Rationale: There are controversial reports on applications of mesenchymal stromal cells (MSCs) in patients with acute respiratory distress syndrome (ARDS). Objectives: We hypothesized that lung microenvironment was the main determinant of beneficial versus detrimental effects of MSCs during ARDS. Methods:
Chuanjiang Dong et al.
Frontiers in microbiology, 10, 3016-3016 (2020-02-06)
As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is a promising antibacterial drug target. Ebselen, an organo-selenium with well-characterized toxicology and pharmacology, was recently reported to have potent antibacterial activity against Staphylococcus aureus. In this paper, we demonstrated that ebselen has
Selcuk Yatmaz et al.
American journal of respiratory cell and molecular biology, 48(1), 17-26 (2012-09-25)
Oxidative stress caused by excessive reactive oxygen species production is implicated in influenza A virus-induced lung disease. Glutathione peroxidase (GPx)-1 is an antioxidant enzyme that may protect lungs from such damage. The objective of this study was to determine if
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