推薦產品
應用
Dendrotoxin-K is suitable for use as a potassium voltage-gated channel subfamily A member 1 (Kv1.1) channel blocker in axon and human embryonic kidney (HEK293) cells. It has also been used as a selective blocker of Kv channels in mice.
生化／生理作用
Dendrotoxin-K (DTXk) is isolated from mamba snake Dendroaspis polylepis and interacts with the β-turn region in the N-terminal sequence of the potassium channel. It inhibits tumor progression in gefitinib-resistant non-small cell lung cancer cells. DTXk induces neuronal damage in the hippocampus via N-methyl-d-aspartate (NMDA) and non-NMDA receptors.
Dendrotoxin-K inhibits potassium channels that contain Kv1.1 protein only.
特點和優勢
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
其他說明
Isolated initially from Dendroaspis polylepis polylepis venom
準備報告
Purified by a modification of the method of Schweitz.
重構
Reconstitute in 1 mL deionized water or buffer (pH 7.5) to yield 10 μM stock
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Analog modulation of spike-evoked transmission in CA 3 circuits is determined by axonal K v1. 1 channels in a time-dependent manner
Bialowas A, et al.
The European Journal of Neuroscience, 41(3), 293-304 (2015)
F C Wang et al.
European journal of biochemistry, 263(1), 222-229 (1999-08-03)
Dendrotoxin (DTX) homologues are powerful blockers of K+ channels that contain certain subfamily Kv1 (1.1-1.6) alpha- and beta-subunits, in (alpha)4(beta)4 stoichiometry. DTXk inhibits potently Kv1.1-containing channels only, whereas alphaDTX is less discriminating, but exhibits highest affinity for Kv1.2. Herein, the
Effects of voltage-gated K+ channel blockers in gefitinib-resistant H460 non-small cell lung cancer cells
Jeon WIL, et al.
Anticancer Research, 32(12), 5279-5284 (2012)
Identification of residues in dendrotoxin K responsible for its discrimination between neuronal K+ channels containing Kv1. 1 and 1.2 alpha subunits
Wang FC, et al.
European Journal of Biochemistry, 263(1), 222-229 (1999)
Cav1. 3 calcium channels are required for normal development of the auditory brainstem
Hirtz JJ, et al.
The Journal of Neuroscience, 31(22), 8280-8294 (2011)
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務