推薦產品
![[des-Gly10, D-Ala6]-LH-RH ethylamide acetate salt hydrate ≥97% (HPLC), powder](/deepweb/assets/sigmaaldrich/product/structures/150/195/13e08743-1592-4a6b-937d-559f571a2193/640/13e08743-1592-4a6b-937d-559f571a2193.png)
生物源
human urine
品質等級
無菌
aseptically processed
形狀
lyophilized powder
效力
≥5,000 I.U. per mg
分子量
37.9 kDa
apparent mol wt 37.9 kDa by SDS-PAGE
drug control
Home Office Schedule 4.2
技術
cell culture | embryo: suitable
雜質
HBV,HCV and HIV, tested negative
溶解度
H2O: 1 mL/vial
saline: 1 mL/vial
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... CGA(1081)
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一般說明
注意：根据糖基化程度的不同，实际分子量与理论值不同。该物质天然形式的理论分子量为 37.9kDa，且包含 2 个亚基：α = 14.9kDa（多肽部分 ~10.2kDa，碳水化合物部分 ~4.7kDa），β = 23.0kDa（多肽部分 ~16.0kDa，碳水化合物部分 ~7.0kDa）。参见 J. Biol. Chem. 248，6796-6827(1973)。
由 92 个氨基酸 α 链组成的糖蛋白激素，与 LH、FSH 和 TSH 相同； 和一个独特的 149 个氨基酸 β 链。由绒毛膜组织产生，负责在妊娠早期维持黄体。也由滋养层细胞肿瘤产生，其特征是游离 hCG β-链升高和高糖基化 hCG。
應用
推荐用于小鼠的超数排卵诱导。
生化／生理作用
Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals. When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
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