C8145

Cefsulodin sodium salt hydrate

third-generation cephalosporin antibiotic

• 同義詞: 7-(D-α-Sulfophenylacetamido)ceph-3-em-3-(4′-carbamoylpyridinium)methyl-4-carboxylate sodium salt
• 經驗公式（希爾表示法）: C₂₂H₁₉N₄NaO₈S₂ · xH₂O
• CAS號碼: 52152-93-9
• 分子量：: 554.53 (anhydrous basis)
• EC號碼: 257-692-4
• MDL號碼: MFCD07793338
• 分類程式碼代碼: 51284140
• PubChem物質ID: 24278340
• NACRES: NA.85

屬性

• 品質等級: 200
• 形狀: powder or crystals
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: cell wall synthesis | interferes
• 儲存溫度: 2-8°C
• SMILES 字串: [Na+].NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S([O-])(=O)=O)C3=O)C([O-])=O)cc1
• InChI: 1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1
• InChI 密鑰: REACMANCWHKJSM-DWBVFMGKSA-M

描述

一般說明

Chemical structure: ß-lactam

應用

Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. Cefuslodin is used in CIN (cefsulodin-Irgasan-novobiocin) agar to select for microorganisms such as E. coli. Cefsulodin is a substrate for rat Oatp1a4. It has been used to study multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across the mouse blood-brain barrier.

Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

生化／生理作用

Cefsulodin is a cephalosporin. Cephalosporins disrupt cell wall synthesis by inhibiting PBP crosslinking of peptidoglycan.

其他說明

Keep container tightly closed in a dry and well-ventilated place.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves