C5923

(-)-可替宁

≥98% (TLC), crystals, nicotine metabolite

• 同義詞: (S)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮, S(-)-1-甲基-5-(3-吡啶基)-2-吡咯烷酮
• 經驗公式（希爾表示法）: C₁₀H₁₂N₂O
• CAS號碼: 486-56-6
• 分子量：: 176.22
• Beilstein: 83099
• EC號碼: 207-634-9
• MDL號碼: MFCD00077696
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278324
• NACRES: NA.77

屬性

• product name: (-)-可替宁, ≥98%
• 品質等級: 200
• 化驗: ≥98%
• 形狀: crystals
• bp: 250 °C/150 mmHg (lit.)
• mp: 40-42 °C (lit.)
• 儲存溫度: 2-8°C
• SMILES 字串: CN1[C@@H](CCC1=O)c2cccnc2
• InChI: 1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
• InChI 密鑰: UIKROCXWUNQSPJ-VIFPVBQESA-N
• 基因資訊: human ... CYP1A2(1544) , CYP2A6(1548) ; mouse ... Cyp2a5(13087)

描述

一般說明

Cotinine is an alkaloid extracted from tobacco leaves. It can cross the blood-brain barrier. Cotinine is used to treat Alzheimer′s disease (AD), schizophrenia and post-traumatic stress disorder (PTSD).

應用

Cotinine has been used:

• for oxygen-glucose deprivation (OGD) studies to model ischemic stroke
• as a standard to determine serum cotinine measurements using liquid chromatography with tandem mass spectrometry (LC-MS/MS)
• to evaluate the adverse developmental potential of cotinine
• to assess cognitive behavior in mice

生化／生理作用

尼古丁在人体内的主要代谢物。

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H315,H319,H335
• 防範說明: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 230.0 °F - closed cup
• 閃點（°C）: 110 °C - closed cup
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves