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Merck
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Key Documents

C4895

Sigma-Aldrich

Cephalexin hydrate

first-generation cephalosporin antibiotic

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About This Item

經驗公式(希爾表示法):
C16H17N3O4S · xH2O
CAS號碼:
分子量::
347.39 (anhydrous basis)
Beilstein:
965503
EC號碼:
MDL號碼:
分類程式碼代碼:
51282503
PubChem物質ID:
NACRES:
NA.85

形狀

powder

pKa 

5.2
7.3

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

InChI

1S/C16H17N3O4S.H2O/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);1H2/t10-,11-,15?;/m1./s1

InChI 密鑰

AVGYWQBCYZHHPN-FNOHQHCYSA-N

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一般說明

Chemical structure: ß-lactam

應用

Cephalexin is a cephalosporin antibiotic used to study the effect of expression, binding, and inhibition of PBP3 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

生化/生理作用

Cephalexin disrupts the synthesis of the peptidoglycan layer of bacterial cell walls which is responsible for cell wall structural integrity. Peptidoglycan synthesis is facilitated by transpeptidases known as penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Cephalexin antibiotics mimic the D-Ala-D-Ala site, thereby competitively inhibiting PBP crosslinking of peptidoglycan.

其他說明

Storage of this product should be in airtight containers and protected from light.

象形圖

Health hazard

訊號詞

Danger

危險聲明

危險分類

Resp. Sens. 1 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


分析證明 (COA)

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Alexander Perniss et al.
Scientific reports, 8(1), 5681-5681 (2018-04-11)
Several species of the Gram-negative genus Bordetella are the cause of respiratory infections in mammals and birds, including whooping cough (pertussis) in humans. Very recently, a novel atypical species, Bordetella pseudohinzii, was isolated from laboratory mice. These mice presented no
Hiroshi Kodaira et al.
The Journal of pharmacology and experimental therapeutics, 339(3), 935-944 (2011-09-22)
This study investigated the impact of the active efflux mediated by P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) at the blood-brain barrier (BBB) on the predictability of the unbound brain concentration (C(u,brain)) by the concentration in the cerebrospinal fluid
Tomoko Sugiura et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(6), 1181-1188 (2008-03-07)
Gastrointestinal (GI) absorption of certain therapeutic agents is thought to be mediated by solute carrier (SLC) transporters, although minimal in vivo evidence has been reported. Here, we show key roles of postsynaptic density 95/disk-large/ZO-1 (PDZ) domain-containing protein, PDZK1, as a
Steven D Coon et al.
American journal of physiology. Gastrointestinal and liver physiology, 305(10), G678-G684 (2013-09-28)
Glucose-dependent insulinotropic polypeptide (GIP) secreted from jejunal mucosal K cells augments insulin secretion and plays a critical role in the pathogenesis of obesity and Type 2 diabetes mellitus. In recent studies, we have shown GIP directly activates Na-glucose cotransporter-1 (SGLT1)
William T Gray et al.
Cell, 177(6), 1632-1648 (2019-06-01)
The scaling of organelles with cell size is thought to be exclusive to eukaryotes. Here, we demonstrate that similar scaling relationships hold for the bacterial nucleoid. Despite the absence of a nuclear membrane, nucleoid size strongly correlates with cell size

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