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Key Documents

C4749

Sigma-Aldrich

羧基酯酶2 人

recombinant, expressed in mouse NSO cells, ≥95% (SDS-PAGE)

同義詞:

CES2, CES2A1

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About This Item

酶委員會編號:
分類程式碼代碼:
12352204
NACRES:
NA.54

重組細胞

expressed in mouse NSO cells

品質等級

化驗

≥95% (SDS-PAGE)

形狀

solution

比活性

≥1.0 EU/μg
30,000 pmol/min-μg protein

分子量

predicted mol wt ~60 kDa

濃度

0.4-0.6 mg/mL

雜質

≤1.0 EU/μg endotoxin

NCBI登錄號

運輸包裝

dry ice

儲存溫度

−70°C

基因資訊

human ... CES2(8824)

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生化/生理作用

人羧酸酯酶2(hCE-2)可识别具有大醇基和小酰基的底物。由于在活性位点口袋中存在构象干扰,其底物特异性可能受到酰基-hCE-2缀合物形成能力的限制。羧基酯酶可催化几种含酯的药物和前药的生物转化,例如血管紧张素转化酶抑制剂(替莫卡普、西拉普利)、抗肿瘤药(卡培他滨)和麻醉药。
可水解酯和酰胺键的丝氨酸酯酶家族成员。羧基酯酶2是一种内质网结合的水解酶,在异源生物解毒和活化含酯治疗剂中起关键作用。羧基酯酶2也可参与海洛因和可卡因等药物的解毒过程。该酶被认为在脂质代谢中起作用。

單位定義

一个酶活性单位是指在pH 7.5、25 °C下,每分钟水解1pmol对硝基苯乙酸酯所需的酶量。

外觀

以含有氯化钠、乙酸钠和20%甘油的溶液形式提供。

象形圖

Health hazard

訊號詞

Danger

危險聲明

防範說明

危險分類

Resp. Sens. 1

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Teruko Imai
Drug metabolism and pharmacokinetics, 21(3), 173-185 (2006-07-22)
Human carboxylesterase 1 (hCE-1, CES1A1, HU1) and carboxylesterase 2 (hCE-2, hiCE, HU3) are a serine esterase involved in both drug metabolism and activation. Although both hCE-1 and hCE-2 are present in several organs, the hydrolase activity of liver and small
B Sànchez-Nogué et al.
Environmental science and pollution research international, 20(5), 3480-3488 (2012-12-06)
The common sole, Solea solea (Linneus, 1758), and the Senegalese sole, Solea senegalensis (Kaup, 1858), are two important commercial species that coexist in the NW Mediterranean. In order to assess the species' ability to respond to chemical insults, a comparison
Marie C Fortin et al.
Drug metabolism and disposition: the biological fate of chemicals, 41(2), 326-331 (2012-12-12)
Studies on therapeutic drug disposition in humans have shown significant alterations as the result of pregnancy. However, it is not known whether pesticide metabolic capacity changes throughout pregnancy, which could affect exposure of the developing brain. We sought to determine
XieMei Tang et al.
Critical reviews in eukaryotic gene expression, 22(3), 179-187 (2012-11-13)
Tuberculosis remains one of the most prevalent and deadly infectious diseases, largely due to the emergence of multidrug-resistant and extensive drug-resistant Mycobacterium tuberculosis, especially the coinfection with HIV. Mycobacterium Ag85 complex (Ag85A, B, and C), with a carboxylesterase consensus sequence
Zhe-Yi Hu et al.
Analytical and bioanalytical chemistry, 405(5), 1695-1704 (2012-12-15)
Dabigatran etexilate (DABE) is an oral prodrug that is rapidly converted by esterases to dabigatran (DAB), a direct inhibitor of thrombin. To elucidate the esterase-mediated metabolic pathway of DABE, a high-performance liquid chromatography/mass spectrometry based metabolite identification and semi-quantitative estimation

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