推薦產品
形狀
liquid
品質等級
反應適用性
reagent type: reductant
技術
affinity chromatography: suitable
應用
life science and biopharma
儲存溫度
2-8°C
應用
A ready-to-use reagent used to couple amine ligands to aldehyde functional groups. The coupling buffer reaction is a reductive amination of the intermediate Schiff′s base to a stable C−N bond.
Cyanoborohydride Coupling Buffer has been used:
- in coupling reactions between amines and glutaraldehyde
- to reduce hydrazone bond to a stable hydrazide bond
- as a component in oligonucleotide reaction mixture for coverslips functionalization
Cyanoborohydride Coupling Buffer is used in affinity chromatography, protein chromatography, activated/functionalized matrices and synthetic reagents. Cyanoborohydride has been used to inform a safe and effective gene-transfer system targeting hepatocytes as well as to develop a method for targeted delivery of anticancer therapeutics to cancer cells in hypoxic areas.
生化／生理作用
Cyanoborohydride Coupling Buffer is a reagent suitable for reductive amination processes, that contributes to transformation of simple alcohols into more complex amines. It is used in the conversion of Schiff base, by reducing it, to form a secondary amine without affecting aldehyde groups on the support.
成分
0.02 M sodium phosphate, pH 7.5, containing 0.2 M sodium chloride and 3.0 g/L sodium cyanoborohydride
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Chronic 2
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Use of polymer supported reagents for clean multi-step organic synthesis: preparation of amines and amine derivatives from alcohols for use in compound library generation
Ley S, et al.
Journal of the Chemical Society. Perkin Transactions 1, 15(27), 2239-2242 (1998)
Christopher A Holden et al.
International journal of nanomedicine, 5, 25-36 (2010-02-18)
Tumors frequently contain hypoxic regions that result from a shortage of oxygen due to poorly organized tumor vasculature. Cancer cells in these areas are resistant to radiation- and chemotherapy, limiting the treatment efficacy. Macrophages have inherent hypoxia-targeting ability and hold
Direct electrical detection of antigen?antibody binding on diamond and silicon substrates using electrical impedance spectroscopy.
Yang W, et al.
Analyst, 132(4), 296-306 (2007)
Binding between the integrin ?X?2 (CD11c/CD18) and heparin.
Vorup-Jensen T, et al.
Test, 282(42), 30869-30877 (2007)
Polymer-supported triacetoxyborohydride: a novel reagent of choice for reductive amination
Bhattacharyya S, et al.
Tetrahedron Letters, 44(27), 4957-4960 (2003)
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